Two different molecularly imprinted polymeric coating techniques for creating sensitive and selective electrochemical sensors for the detection of Ribavirin

Çetinkaya, Ahmet; Ünal, Mehmet Altay; Nazır, Hasan; Çorman, M. Emin; Uzun, Lokman; Özkan, Síbel A.

doi:10.1016/j.snb.2023.133914

Cited by 22 publications

(5 citation statements)

References 29 publications

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“…Increasing the AM ratio leads to better binding of the template molecule ACV to the polymer, hence making it more challenging to remove the template molecule from the MIP surface. Similar results have also been reported for the findings obtained from similar studies in the literature …”

Section: Resultssupporting

confidence: 92%

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Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir

Al Faysal,

Cetinkaya,

Kaya

et al. 2024

ACS Omega

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Acyclovir (ACV), a synthetic nucleoside derivative of purine, is one of the most potent antiviral medications recommended in the specific management of varicella-zoster and herpes simplex viruses. The molecularly imprinted polymer (MIP) was utilized to create an effective and specific electrochemical sensor using a straightforward photopolymerization process to determine ACV. The polymeric thin coating was developed using the template molecule ACV, a functional monomer acrylamide, a basic monomer 2-hydroxyethyl methacrylate, a cross-linker ethylene glycol dimethacrylate, and a photoinitiator 2-hydroxy-2-methyl propiophenone on the exterior of the glassy carbon electrode (GCE). Scanning electron microscopy, attenuated total reflectance−Fourier transform infrared spectroscopy, electrochemical impedance spectroscopy, and cyclic voltammetry were employed for the purpose of characterizing the constructed sensor (AM-ACV@MIP/GCE). Differential pulse voltammetry and a 5 mM ferrocyanide/ferricyanide ([Fe(CN) 6 ] 3−/4− ) redox reagent were used to detect the ACV binding to the specific cavities on MIP. The study involves density functional theory (DFT) calculations, which were conducted to investigate template-functional monomer interactions thoroughly, calculate template-functional monomer interaction energies, and determine the optimal template/functional monomer ratio. DFT calculations were performed using Becke's three-parameter hybrid functional with the Lee−Yang−Parr correlation functional (B3LYP) method and 6-31G(d,p) basis set. The sensor exhibits linear performance throughout the concentration region 1 × 10 −11 to 1 × 10 −10 M, and the limit of detection and limit of quantification were 7.15 × 10 −13 M and 2.38 × 10 −12 M, respectively. For the electrochemical study of ACV, the sensor demonstrated high accuracy, precision, robustness, and a short detection time. Furthermore, the developed electrochemical sensor exhibited exceptional recovery in tablet dosage form and commercial human blood samples, with recoveries of 99.40 and 100.44%, respectively. The findings showed that the AM-ACV@MIP/GCE sensor would effectively be used to directly assess pharmaceuticals from actual specimens and would particularly detect ACV compared to structurally similar pharmaceutical compounds.

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Section: Resultssupporting

confidence: 92%

“…Similar results have also been reported for the findings obtained from similar studies in the literature. 40 3.2. Surface Characterization of the Developed Sensor.…”

Section: Computational Resultsmentioning

confidence: 99%

Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir

Al Faysal,

Cetinkaya,

Kaya

et al. 2024

ACS Omega

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“…LOD = 3(SD/S) and LOQ = 10(SD/S), where SD represents the standard deviation of the y intercept and S represents the mean slope. 47,48 The LOD and LOQ of this sensing platform are 0.487 nM and 1.623 nM, respectively. The estimated sensitivity of the IMQ is 7.558 μA μM −1 cm −2 .…”

Section: Resultsmentioning

confidence: 99%

Disposable Electrochemical Sensor Based on MXene/Graphene Nanoplatelets/Ionic Liquid for the Determination of Anticancer Drug Imiquimod

Kalambate,

Primpray,

Kamsong

et al. 2023

J. Electrochem. Soc.

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This study describes the development of a novel, ultrasensitive, and selective electrochemical sensor to determine imiquimod (IMQ) using a screen-printed carbon electrode (SPCE) modified with MXene (Ti3C2Tx), graphene nanoplatelets, and ionic liquid (Ti3C2Tx/GNPs/IL). This work reveals the synergistic effect of Ti3C2Tx, GNPs, and IL, where Ti3C2Tx and GNPs provide a large active electrode area and excellent electron transport, and IL exhibits remarkable electrocatalytic behavior. Benefiting from the excellent electrochemical properties of the composite, the developed sensing platform enabled superior electrochemical performance for IMQ in the broad linear range of 0.071–92.0 μM (R2 = 0.999) with a limit of detection (LOD) of 0.487 nM and a detection sensitivity of 7.558 μA μM−1 cm−2. Meanwhile, the sensor has shown good repeatability, reproducibility, stability, and anti-interference ability and has been subsequently used to detect IMQ in cream formulations with satisfactory recoveries (98.33%–99.34%) and lower relative standard deviations (<3%). The findings indicate that the newly developed sensor can contribute to the development of a portable, robust, and high-performance sensing strategy for multidisciplinary targets.

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“…In addition, with the use of less solvent, it is both less economically costly and a more environmentally friendly method of analysis without causing environmental pollution. 37–39…”

Section: Introductionmentioning

confidence: 99%

A novel electrochemical sensor based on a molecularly imprinted polymer for highly selective and sensitive determination of rutin from herbal supplements and plant extracts

Hurkul,

Yayla,

Cetinkaya

et al. 2024

Anal. Methods

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Two different molecularly imprinted polymeric coating techniques for creating sensitive and selective electrochemical sensors for the detection of Ribavirin

Cited by 22 publications

References 29 publications

Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir

Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir

Disposable Electrochemical Sensor Based on MXene/Graphene Nanoplatelets/Ionic Liquid for the Determination of Anticancer Drug Imiquimod

A novel electrochemical sensor based on a molecularly imprinted polymer for highly selective and sensitive determination of rutin from herbal supplements and plant extracts

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