Two cases of delayed granulomatous reactions to the cosmetic filler Dermalive^®, a hyaluronic acid and acrylic hydrogel

Abstract

References1 Frieling U, Bonsmann G, Schwarz T et al. Treatment of severe lichen planus with mycophenolate mofetil. J Am Acad Dermatol 2003; 49:1063-6. 2 Eisman S, Orteu CH. Recalcitrant erosive flexural lichen planus: successful treatment with a combination of thalidomide and 0AE1% tacrolimus ointment. Clin Exp Dermatol 2004; 29:268-70. 3 Erdem MT, Gulec AI, Kiziltunc A et al. Increased serum levels of tumor necrosis factor alpha in lichen planus. Dermatology 2003; 207:367-70. 4 Simon M Jr, Gruschwitz MS. In situ expression and serum levels of tumour necrosis factor alpha receptors in patients with lichen planus. Acta Derm Venereol (Stockh) 1997; 77:191-3. 5 Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol 2002; 46:207-14. 6 Lear JT, English JS. Erosive and generalized lichen planus responsive to azathioprine. Clin Exp Dermatol 1996; 21:56-7. 7 Kopp H, Reymann FE. Lichen planus treated with Grenz rays; preliminary report. Acta Derm Venereol (Stockh) 1956; 36:477-81. 8 Cribier B, Frances C, Chosidow O. Treatment of lichen planus. An evidence-based medicine analysis of efficacy.

Adverse reactions to injectable soft tissue fillers

“…245 Granulomatous reactions to Dermalive and their histopathologic features have been well described. 1,82,121,129,222,223,[246][247][248][249][250] They consist of nodular granulomatous infiltrates involving the reticular dermis and superficial hypodermis. The epidermis and superficial dermis are usually spared.…”

Erratum: Corrigendum

“…All are more experience-based than evidence-based and include local steroid injection and laser excision, but both have limitations. 7 To our knowledge this case is possibly one of the longest reported delayed reactions to dermal fillers and with permanently scarred soft tissues. In a litigious society general dental practitioners using these fillers should be aware of these possible complications.…”

Granulomatous Reaction After Injection of a New Resorbable Filler Novabel

“…Dermalive appears as translucent, irregular, nonbirefringent, polygonal particles of varying sizes, some with a pinkish color around their rim. [3][4][5][6][7] Artecoll consists of round, translucent, uniformly sized and shaped nonbirefringent particles. 3,8,9 Bioplastique (dimethylsiloxane) presents as irregularly shaped cystic structures containing jagged, translucent, nonbirefringent, popcorn-like particles.…”