volume 66, issue 6, P3740-3748 1992
DOI: 10.1128/jvi.66.6.3740-3748.1992
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F Thierry, G Spyrou, M Yaniv, P Howley

Abstract: The activity and epithelial tropism of the human papillomavirus type 18 P105 early promoter, which directs the synthesis of the E6 and E7 transforming genes, are controlled by cis elements included in the viral long control region. To identify potential cellular regulators of this promoter, we mutagenized one or both of the 5'-TGACTAA-3' cis elements capable of interacting with the AP1 transcription factor, which is composed either of homodimers or heterodimers of the Jun products or of heterodimers of Jun and…

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