Two-and-a-Half Years' Experimental Work on the Sulphone Group of Drugs

Abstract

This patient has had a history of l eprosy since I9I7 and illustrates the usual , experience in such cases of having been "'Bacteriologic index. To estimate the bacteriologic index add up the total numuer of positive smears and divide by sixteen. The bacteriologic index will thus vary from 6.uo to 0, the former being from a case where all smears are 6 plus and the latter from the case which shows no bacilli in any of the smears taken. (e.g. If the plus values of all the sixteen smears added up gives a total of 64, then the bacteriologic index would be 6 4-:-16 T 4.) The index in this paper is taken to the nearest digit. Decimal places are considered of little value except when the index falls beloll' 0. .5 when thE' f'igure is indicated by 0.5- .

In-vitro activity of sitafloxacin (DU-6859a), either singly or in combination with rifampin analogs, against Mycobacterium leprae

“…2 This was followed by other firstline drugs, such as clofazimine 3 in 1962 and rifampin 4 in 1970. Dapsone-resistant leprosy was first proved by Petit and Rees in 1964, 5 while resistance to rifampin 6 and to clofazimine 7 was subsequently reported.…”

Global surveillance system to monitor the development of drug resistance in Mycobacterium leprae

“…12 Injectable promin was replaced by a more effective oral sulfone, dapsone (4-4′-diaminodiphenyl sulfone, DDS), 6 years later. 13,14 Rifampicin, clofazimine, and minocycline were introduced subsequently.…”

Trial of High Dosages of Dapsone in the Treatment of Tuberculoid Leprosy

“…However, Chang et al (1952) reported a high safety level in the sulphones. Cochrane (1952) suggested that the basis of their proper use is to start with small doses of dapsone and gradually increase them to the maximum dose. The question that arises is: need dapsone be started in low dosage if the patients tolerate the drug well?…”