Twice-Weekly Topical Corticosteroid Therapy May Reduce Atopic Dermatitis Relapses

Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials

“…Interestingly, 0·05% fluticasone propionate cream appears to be more efficacious to prevent AE flares than 0·005% fluticasone propionate ointment. As previously discussed by Williams 25 this finding may be explained by the 10‐fold difference in concentration of active ingredient in the cream. However, the different concentrations in the cream vs. ointment were specifically formulated to provide equivalent potency as determined by the established vasoconstrictor assay, but the assay may not accurately reflect clinical potency.…”

“…This issue raised the question whether proactive anti-inflammatory treatment really did prevent existing sites of AE from flaring up again, or whether the observed efficacy is at least partly explained by early treatment of newly occurring sites of AE. 25 The presented meta-regression analysis suggests that the study results were not systematically influenced by treatment of newly occurring sites. However, we are aware that the limited number of studies included in the meta-regression analysis might have introduced limited statistical power.…”

“…Most trials used anti‐inflammatory treatment not only on previously affected sites, but also for new AE lesions. This issue raised the question whether proactive anti‐inflammatory treatment really did prevent existing sites of AE from flaring up again, or whether the observed efficacy is at least partly explained by early treatment of newly occurring sites of AE 25 . The presented meta‐regression analysis suggests that the study results were not systematically influenced by treatment of newly occurring sites.…”

“…24 Most trials used anti-inflammatory treatment not only on previously affected sites, but also for new AE lesions. 25 In total, four cases of incident cancer were observed under proactive therapy with topical tacrolimus. 25 The presented meta-regression analysis suggests that the study results were not systematically influenced by treatment of newly occurring sites.…”

Efficacy of moisturizers in paediatric atopic dermatitis: A systematic review and meta-analysis of randomised controlled trials

“…30,31,33 Thus, the efficacy of moisturizer may be overestimated in these studies. 26,28 Imprecision was mainly due to limited sample sizes and wide confidence intervals. Similar to limitations faced by the previous meta-analysis, our findings must be interpreted with great caution due to little confidence in the effect estimates.…”