Twenty percent of biopsy specimens from sun-exposed skin of normal young adults demonstrate positive immunofluorescence

Fabre, V. C.

doi:10.1001/archderm.127.7.1006

Cited by 24 publications

(16 citation statements)

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“…However, a weak decoration with IgM along the DEJ is also common in sun-exposed skin of patients who do not have LE. It was demonstrated that healthy sun-exposed skin may show a weak interrupted linear or granular pattern of IgM and C1q deposits at the DEJ in nearly 25% of samples, but only 5% of them showed the presence of IgG, IgA, or complement component 3 (C3) 12,13. Taking these observations into account, in line with Crowson and Magro,6 we suggest that LBT should be considered positive when deposits of IgM in sun-exposed skin form a continuous band over at least 50% of the width of the biopsy specimen which is at least moderate in intensity.…”

Section: Sensitivity and Specificity Of The Lbtmentioning

confidence: 99%

The lupus band test in systemic lupus erythematosus patients

Reich¹,

Marcinow²,

Białynicki‐Birula³

2011

TCRM

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The lupus band test (LBT) is a diagnostic procedure that is used to detect deposits of immunoglobulins and complement components along the dermoepidermal junction in patients with lupus erythematosus (LE). The LBT is positive in about 70%–80% of sun-exposed non-lesional skin specimens obtained from patients with systemic LE (SLE), and in about 55% of SLE cases if sun-protected nonlesional skin is analyzed. In patients with cutaneous LE only, the lesional skin usually shows a positive LBT. The LBT helps in differentiating LE from other similar skin conditions and may also be helpful in making the diagnosis of SLE in subjects with no specific cutaneous lesions. Furthermore, a positive LBT may be applied as a prognostic parameter for LE patients. However, the correct interpretation of this test requires detailed knowledge of the site of the biopsy, deposit components, morphology and brightness of the immunofluorescent band, and other associated serologic findings, as well as the response to treatment. It must be emphasized that LBT is a laboratory procedure that should always be interpreted in conjunction with clinical findings and other serological and immunopathological parameters.

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Section: Sensitivity and Specificity Of The Lbtmentioning

confidence: 99%

The lupus band test in systemic lupus erythematosus patients

Reich¹,

Marcinow²,

Białynicki‐Birula³

2011

TCRM

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“…33,34,48 However, the diagnos- tic significance of immunohistological examination has been the subject of much controversy during recent years. 49 Since immune deposits are not specific for LE (similar deposits can be found in nonlesional and sundamaged skin or in other skin diseases [49][50][51] ), considerable caution must be taken when interpreting the results of immunopathologic findings in lesional and nonlesional skin specimens. 30 Photosensitivity, one of the 11 ARA criteria for the diagnosis of SLE, 24 was investigated in all of the 40 patients with LET by means of experimental reproduction of skin lesions after UV radiation.…”

Section: Commentmentioning

confidence: 99%

Lupus Erythematosus Tumidus

Kuhn¹,

Richter-Hintz²,

Oslislo³

et al. 2000

Arch Dermatol

212

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“…In our case, the histopathological findings from the eruptions did not show typical lupus erythematosus reactions, but did show perifollicular lymphoid cell infiltration and linear deposition of IgM on the dermo-epidermal junction. There is also the possibility that the deposition of IgM on the dermo-epidermal junction in light-exposed skin is nonspecific (8). In drug induced lupus erythematosus-like syndrome, typical histological changes are not usually found (4,6,7).…”

Section: Discussionmentioning

confidence: 99%

Lupus Erythematosus‐like Syndrome Induced by Thiamazole and Propylthiouracil

Sato‐Matsumura

Koizumi

Matsumura

et al. 1994

The Journal of Dermatology

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A 17-year-old Japanese woman developed a lupus erythematosus-like syndrome during treatment for Graves' disease with thiamazole and propylthiouracil. Erythema, arthralgia, and low grade fever developed during therapy with thiamazole; purplish-red erythema developed during therapy with propylthiouracil. Antinuclear antibodies, anti-single-stranded DNA antibodies, and anti-double-stranded DNA antibodies were positive throughout the administration of these two drugs. Eruptions and other symptoms improved after their discontinuation. The titers of autoantibodies also decreased two months after withdrawal. The patient had HLA DR4.

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Twenty percent of biopsy specimens from sun-exposed skin of normal young adults demonstrate positive immunofluorescence

Cited by 24 publications

References 0 publications

The lupus band test in systemic lupus erythematosus patients

The lupus band test in systemic lupus erythematosus patients

Lupus Erythematosus Tumidus

Lupus Erythematosus‐like Syndrome Induced by Thiamazole and Propylthiouracil

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