Twelve oxo-eicosatetraenoic acid induces fetal membrane release after delivery in cows

Kamada, Hiroki; Matsui, Yoshitaka; Sakurai, Yoshie; Tanigawa, Tamako; Itoh, M.; Kawamoto, Satoshi; Kai, Kenzo; Sasaki, T; Takahashi, Kentaro; Hayashi, Masayuki; Takayama, Yoshiharu; Nakamura, Masato; Kadokawa, Hiroya; Ueda, Yusuke; Sutoh, Madoka; Murai, Masaru

doi:10.1016/j.placenta.2011.11.001

Cited by 11 publications

(16 citation statements)

References 25 publications

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“…5), was identified as a metabolite of endogenous AA following stimulation of nervous tissue from the marine mollusk, Aplysia californica and was found to induce changes in neuron potential in this species similar to those elicited by histamine [181]. A role for 12-oxo-ETE in the release of fetal membranes in cows following delivery has been reported [115]. 12-Oxo-ETE, albeit at a rather high concentration (10 µM), but not 5-oxo-ETE, 15-oxo-ETE or 12S-HETE, induced the detachment of cultured placental fibroblasts, which was thought to be mediated by the activation of metalloproteinases.…”

Section: Biological Actions Of Hetes and Oxoetesmentioning

confidence: 99%

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

Powell

Rokach

2015

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

257

206

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Arachidonic acid can be oxygenated by a variety of different enzymes, including lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a complex mixture of oxygenated products as a result of lipid peroxidation. The initial products in these reactions are hydroperoxyeicosatetraenoic acids (HpETEs) and hydroxyeicosatetraenoic acids (HETEs). Oxoeicosatetraenoic acids (oxo-ETEs) can be formed by the actions of various dehydrogenases on HETEs or by dehydration of HpETEs. Although a large number of different HETEs and oxo-ETEs have been identified, this review will focus principally on 5-oxo-ETE, 5S-HETE, 12S-HETE, and 15S-HETE. Other related arachidonic acid metabolites will also be discussed in less detail. 5-Oxo-ETE is synthesized by oxidation of the 5-lipoxygenase product 5S-HETE by the selective enzyme, 5-hydroxyeicosanoid dehydrogenase. It actions are mediated by the selective OXE receptor, which is highly expressed on eosinophils, suggesting that it may be important in eosinophilic diseases such as asthma. 5-Oxo-ETE also appears to stimulate tumor cell proliferation and may also be involved in cancer. Highly selective and potent OXE receptor antagonists have recently become available and could help to clarify its pathophysiological role. The 12-lipoxygenase product 12S-HETE acts by the GPR31 receptor and promotes tumor cell proliferation and metastasis and could therefore be a promising target in cancer therapy. It may also be involved as a proinflammatory mediator in diabetes. In contrast, 15S-HETE may have a protective effect in cancer. In addition to GPCRs, higher concentration of HETEs and oxo-ETEs can activate peroxisome proliferator-activated receptors (PPARs) and could potentially regulate a variety of processes by this mechanism.

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Section: Biological Actions Of Hetes and Oxoetesmentioning

confidence: 99%

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

Powell

Rokach

2015

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

257

206

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“…Our observations of the PA system suggest that if transcription of the entire PA system changes between late gestation and parturition, as observed by other investigators (Streyl et al, ), these changes depend on the fetus traversing the birth canal. An endocrine signal(s) has been recently proposed for such an event (Kamada et al, ), which appear to be secreted after fetal expulsion; this lag may account for the variation in time between expulsion of the calf and expulsion of the placenta. Differences between our data and that from other investigators (Streyl et al, ) may be due to differences in timing of tissue collection, in cDNA preparation (oligo‐dT vs. oligo‐dT and random decamers), in the mechanisms responsible for placental separation between cattle and sheep, or in method of assessment (e.g., inherent differences between microarray and reverse transcriptase quantitative PCR).…”

Section: Discussionmentioning

confidence: 99%

The plasminogen activator system in the ovine placentome during late gestation and stage‐two of parturition

McNeel

Cushman

Vallet

2013

Molecular Reproduction Devel

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The process of placental separation is not completely understood. In domestic animals, especially cattle, it is important that expulsion of the fetal membranes takes place in a timely manner in order to achieve maximal reproductive efficiency. The activity of the matrix-metalloprotease (MMP) family of proteases is known to be reduced in placentomes from cases of retained placenta. Members of the MMP family are known to be activated by the plasminogen activator (PA) family of proteases. We hypothesized that the expression and activity of the PA family increase in the cotyledon and/or caruncle as parturition approaches, with maximal expression and activity at parturition. To test this hypothesis, we performed reverse-transcriptase quantitative PCR and plasminogen-casein zymography to detect the presence and activity of PA family members in the placentome leading up to and during parturition in spontaneous and dexamethasone-induced parturient ewes. The results from our experiments indicated that serine proteases inhibitor E1 (SERPINE1) mRNA abundance in the cotyledon was different between treatment groups (P = 0.0002). In the caruncle, gene expression for plasminogen activator urokinase-type (PLAU) was different (P = 0.0154), and there was a strong trend for differences in SERPINE1 expression (P = 0.0565). These results demonstrate that expression of the PA system in the placentome changes from late pregnancy to parturition, and the presence or activity of these enzymes may occur after fetal expulsion.

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“…12-KETE is a strong candidate of signal for placental expulsion at delivery. Our previous paper showed the response of fibroblasts derived from placentome to 12-KETE [9]. In the present study, we investigated the response of trophoblast cells (a model of placenta cell) derived from bovine blastocyst to 12-KETE.…”

Section: Introductionmentioning

confidence: 95%

“…In a previous study, we successfully induced placental expulsion via the administration of 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-KETE), a metabolite of eicosatetraenoic acid (Ara), to delivery-induced cows [9]. 12-KETE is a strong candidate of signal for placental expulsion at delivery.…”

Section: Introductionmentioning

confidence: 99%

12-Oxoeicosatetraenoic acid, a candidate signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells

Kamada¹

2023

Anim Biosci

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Bovine trophoblast cells derived from blastocysts were used. They were cocultured with or without fibroblasts derived from bovine placentome and/or bovine uterine epithelial cells. 12-KETE was added to the culture medium.Results: Bovine trophoblast cells contained binucleate cells and strongly expressed CDX-2 genes. Addition of 12-KETE to the trophoblast cell colony without feeder cells or that on a fibroblast monolayer induced rapid exfoliation of the colony. After 12-KETE addition, trophoblast cells emitted strong fluorescence caused by the degradation of dyequenched collagen, indicating that 12-KETE activated matrix metalloproteinase of the trophoblast cells. Exfoliated cell colonies were stained with YOPRO-1, but not propidium iodide. Moreover, DNA fragmentation and Bax gene (apoptosis stimulator) upregulation were observed in exfoliated cells, indicating that 12-KETE induced trophoblast cell apoptosis. These results were consistent with previous in vivo observations; however, even a lower concentration of 12-KETE activated trophoblast protease. Meanwhile, fibroblasts derived from the bovine placentome converted arachidonic acid to 12-KETE. Conclusion:These observations indicate that 12-KETE may serve as a signal for placenta separation at delivery.

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Twelve oxo-eicosatetraenoic acid induces fetal membrane release after delivery in cows

Cited by 11 publications

References 25 publications

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

The plasminogen activator system in the ovine placentome during late gestation and stage‐two of parturition

12-Oxoeicosatetraenoic acid, a candidate signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells

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