Tutorial: guidelines for standardized performance tests for electrodes intended for neural interfaces and bioelectronics

Boehler, Christian; Carli, Stefano; Fadiga, Luciano; Stieglitz, Thomas; Asplund, Maria

doi:10.1038/s41596-020-0389-2

Cited by 153 publications

(227 citation statements)

References 98 publications

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“…The low impedance over a wide frequency range is promising for favourable signal-to-noise ratio in recordings. [8] The high CSC (an index of the electrodes’ charge transfer capabilities) is promising for neurostimulation. It must be noted though that the CSC is an overestimation of the charge transfer potential of the electrodes: in fact when stimulating in-vivo, at high frequencies and short pulses, only the superficial layers of the bulk PEDOT:PSS film will be active.…”

Section: Resultsmentioning

confidence: 99%

“…It must be noted though that the CSC is an overestimation of the charge transfer potential of the electrodes: in fact when stimulating in-vivo, at high frequencies and short pulses, only the superficial layers of the bulk PEDOT:PSS film will be active. [8] Thus, the CIC was expected to be lower (5-20% of the CSC for metals and oxides). [25] PEDOT:PSS electrodes reported a CIC higher than the total CSC with high variability among electrodes.…”

Section: Resultsmentioning

confidence: 99%

“…A severe foreign body reaction response can affect the performances of a neural interface. [8][9][10][11] For stent technology, this limitation already led to the development of bioresorbable devices, allowing a better interaction with the tissue and placement in mechanically solicited areas. [12] These present limitations motivated us to develop a degradable stentrode technology based on polymeric materials and microfabrication techniques.…”

Section: Introductionmentioning

confidence: 99%

“…A severe foreign body reaction response can affect the performances of a neural interface. [8–11] For stent technology, this limitation already led to the development of bioresorbable devices, allowing a better interaction with the tissue and placement in mechanically solicited areas. [12]…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Degradable endovascular neural interface for minimally invasive neural recording and stimulation

Fanelli

Ferlauto

et al. 2021

Preprint

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Neural recording and stimulation have been widely used to mitigate traumatic injuries, neurodegenerative diseases or mental disorders. Most neural interfaces commonly require invasive surgery, potentially entailing both transient and permanent complications. A promising strategy designed to overcome these risks involves exploiting the cerebrovascular system as an access route to the neural tissue. Here we present a novel endovascular neural interface for neural recording and stimulation, fully polymeric and degradable. This concept might allow for better integration of the device in the body, reduced inflammatory reaction, the possibility of replacing the implant after degradation, and avoiding removal surgeries. The vasculature’s strategic distribution and the use of soft polymers for the device’s fabrication will permit targeting both the brain vasculature and the peripheral system. Therefore, this novel endovascular neural interface will broaden the range of applications from neurological diseases and mental disorders to bioelectronics medicine.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Degradable endovascular neural interface for minimally invasive neural recording and stimulation

Fanelli

Ferlauto

et al. 2021

Preprint

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show abstract

“…Recent publicity surrounding a coin-size computer chip in a pig's brain has placed the spotlight on the field of neurointerfaces (Lewis, 2020). Implantable microelectrode arrays (MEAs), or neural probes, enable the study of brain activity and present promising treatment and therapeutic options for neurological conditions (Boehler et al, 2020). These range from motor and sensory impairments such as spinal cord injuries and hearing loss, to neuropsychiatric disorders including dementia, clinical depression and insomnia.…”

Section: Introductionmentioning

confidence: 99%

More Than Cell Markers: Understanding Heterogeneous Glial Responses to Implantable Neural Devices

Bouadi

Tay

2021

Front. Cell. Neurosci.

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Carbon Nanotube Array‐Based Flexible Multifunctional Electrodes to Record Electrophysiology and Ions on the Cerebral Cortex in Real Time

Yang

Qian

Wang

et al. 2022

Adv Funct Materials

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Electrophysiology and neurochemicals such as Ca2+, K+, and Na+ on the cerebral cortex can synergistically reflect the neurophysiological states. Transparent electrodes have been reported to record electrocorticography (ECoG) and image Ca2+ on the cerebral cortex surface. However, Ca2+ imaging is unable to track extracellular changes correlated with neural activities such as anesthesia, and imaging techniques to monitor K+ and Na+ are yet unavailable. Here, a flexible multifunctional electrode (FME) based on carbon nanotube array is presented to record ECoG and extracellular ions of Ca2+, K+, and Na+. The FME exhibits both lower impedance and higher capacitance than that of conventional gold electrodes. It simultaneously shows stable ion‐sensing performance and long‐term biocompatibility. The FME realizes multi‐model recording of ECoG and extracellular ions on the cerebral cortex surface of rats, providing an effective detection method for brain science.

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Tutorial: guidelines for standardized performance tests for electrodes intended for neural interfaces and bioelectronics

Cited by 153 publications

References 98 publications

Degradable endovascular neural interface for minimally invasive neural recording and stimulation

Degradable endovascular neural interface for minimally invasive neural recording and stimulation

More Than Cell Markers: Understanding Heterogeneous Glial Responses to Implantable Neural Devices

Carbon Nanotube Array‐Based Flexible Multifunctional Electrodes to Record Electrophysiology and Ions on the Cerebral Cortex in Real Time

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