Turnover of quorum sensing signal molecules modulates cross‐kingdom signalling

Tait, Karen; Williamson, Holly; Atkinson, Steve; Williams, Paul; Cámara, Miguel; Joint, Ian

doi:10.1111/j.1462-2920.2009.01904.x

Cited by 89 publications

(75 citation statements)

References 40 publications

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“…In natural seawater, AHLs are short-lived and subject to both abiotic lactonolysis and enzymatic degradation (Decho et al, 2009;Hmelo and Van Mooy, 2009;Tait et al, 2009b). Thus, the presence of AHLs in Trichodesmium colonies indicates that QS was active among epibiotic bacteria.…”

Section: Attenuation Of Apase Activity By Ai-2mentioning

confidence: 99%

Quorum sensing control of phosphorus acquisition in Trichodesmium consortia

et al. 2011

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Colonies of the cyanobacterium Trichodesmium are abundant in the oligotrophic ocean, and through their ability to fix both CO 2 and N 2 , have pivotal roles in the cycling of carbon and nitrogen in these highly nutrient-depleted environments. Trichodesmium colonies host complex consortia of epibiotic heterotrophic bacteria, and yet, the regulation of nutrient acquisition by these epibionts is poorly understood. We present evidence that epibiotic bacteria in Trichodesmium consortia use quorum sensing (QS) to regulate the activity of alkaline phosphatases (APases), enzymes used by epibionts in the acquisition of phosphate from dissolved-organic phosphorus molecules. A class of QS molecules, acylated homoserine lactones (AHLs), were produced by cultivated epibionts, and adding these AHLs to wild Trichodesmium colonies collected at sea led to a consistent doubling of APase activity. By contrast, amendments of (S)-4,5-dihydroxy-2,3-pentanedione (DPD)-the precursor to the autoinducer-2 (AI-2) family of universal interspecies signaling molecules-led to the attenuation of APase activity. In addition, colonies collected at sea were found by high performance liquid chromatography/mass spectrometry to contain both AHLs and AI-2. Both types of molecules turned over rapidly, an observation we ascribe to quorum quenching. Our results reveal a complex chemical interplay among epibionts using AHLs and AI-2 to control access to phosphate in dissolved-organic phosphorus.

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Section: Attenuation Of Apase Activity By Ai-2mentioning

confidence: 99%

Quorum sensing control of phosphorus acquisition in Trichodesmium consortia

et al. 2011

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“…It should be noted that homology searches will miss acyl-HSL synthase genes of previously undiscovered families. For instance, some marine bacteria produce acyl-HSLs but do not encode LuxI or LuxM homologs (52). The HMP does not report the presence of Acinetobacter baumannii in stool samples, but A. baumannii was recently found within mouse intestinal crypts (53).…”

Section: Potentially Positive Results From Genomics and Metagenomicsmentioning

confidence: 99%

“…With regard to enzymatic degradation, numerous enzymatic activities that act on acyl-HSLs have been discovered. These include acylases, oxidoreductases, and lactonases (52,(64)(65)(66)(67)(68)(69)(70)(71). BLAST analysis of the gastrointestinal HMP reference genomes with the lactonase AhlK reveals one homolog in a Klebsiella species (Table 3).…”

Section: The Possibility Of Degradationmentioning

confidence: 99%

Are There Acyl-Homoserine Lactones within Mammalian Intestines?

2013

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Many Proteobacteria are capable of quorum sensing using N-acyl-homoserine lactone (acyl-HSL) signaling molecules that are synthesized by LuxI or LuxM homologs and detected by transcription factors of the LuxR family. Most quorum-sensing species have at least one LuxR and one LuxI homolog. However, members of the Escherichia, Salmonella, Klebsiella, and Enterobacter genera possess only a single LuxR homolog, SdiA, and no acyl-HSL synthase. The most obvious hypothesis is that these organisms are eavesdropping on acyl-HSL production within the complex microbial communities of the mammalian intestinal tract. However, there is currently no evidence of acyl-HSLs being produced within normal intestinal communities. A few intestinal pathogens, including Yersinia enterocolitica, do produce acyl-HSLs, and Salmonella can detect them during infection. Therefore, a more refined hypothesis is that SdiA orthologs are used for eavesdropping on other quorum-sensing pathogens in the host. However, the lack of acyl-HSL signaling among the normal intestinal residents is a surprising finding given the complexity of intestinal communities. In this review, we examine the evidence for and against the possibility of acyl-HSL signaling molecules in the mammalian intestine and discuss the possibility that related signaling molecules might be present and awaiting discovery.

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“…On the other hand, compounds with QSI activity found application in the antifoulant technologies, because macro-organisms are able for sensing bacterial QS signaling molecules to settle and metamorphose, selecting like that the proper biofilm conditions for its development. Following these concepts it is possible to assume that bacterial biofilm and the signaling molecules present in a surface, may influence the colonization of surfaces and the development of phenomena such as biofouling (Joint et al, 2007;Marshall et al,2006;Tait et al, 2009). …”

Section: Introductionmentioning

confidence: 99%