ABSTRACT. Objective: Previous research identifi ed a high-risk subgroup of students who experience high levels of multiple and repeated alcohol-related consequences (MRC group). Although they consist of 20% of the population and account for nearly 50% of the consequences, the MRC group has not been the focus of etiological or prevention research. The present study identifi ed pre-college profi les of psychosocial and behavioral characteristics and examined the association between these profi les and membership in the MRC group. Method: The sample consisted of 370 fi rst-year college students (57% female) recruited in the summer before college. Participants reported on typical drinking, alcohol-related risky and protective drinking behaviors, alcohol beliefs, descriptive and injunctive norms, and alcohol-related consequences at three time points over 15 months. Results: Latent profi le analysis identifi ed four baseline student profi les: extreme-consequence drinkers, high-risk drinkers, protective drinkers, and nondrinkers. Logistic regression revealed that, when the high-risk drinkers were used as the reference group, both the protective drinkers and the nondrinkers were signifi cantly less likely to be members of the MRC group, whereas the extremeconsequence drinkers were at increased odds of being in the MRC group, even after fi rst-year drinking was controlled for. Student profi les and previously identifi ed parental profi les both had unique main effects on MRC group membership, but there was no signifi cant interaction between parental and student profi les. Conclusions: Findings suggest ways that brief interventions can be tailored for students and parents in relation to the MRC group. (J. Stud. Alcohol Drugs, 74, 542-551, 2013)