Turmeric Plays Protective Role against Paraben Induced Hepatic and Renal Lesions in Albino Mice

Ara, Chaman; Asmatullah, Asmatullah; Riaz, Zainab; Memoona, Memoona; Chaudhary, Asma; Andleeb, Shagufta

doi:10.17582/journal.pujz/2020.35.1.07.12

Cited by 1 publication

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“…Turmeric is used in traditional medicine to treat liver and respiratory disorders, allergies, sinusitis, and anorexia (Razavi et al, 2021). At present, this herb is also known to have antirheumatic (Nakisa & Rahbardar, 2021), anti‐cancer (Gurer et al, 2022), antidotal (Ara et al, 2020; Hosseini & Hosseinzadeh, 2018), anti‐hypertriglyceridemia (Mollazadeh et al, 2019), hypoglycemic (El‐Hadary & Sitohy, 2021), anti‐depressive (Alavi et al, 2021), hepatoprotective, anti‐obesity (Vafaeipour et al, 2022), cardioprotective (Akhter & Nahar, 2022), and anti‐microbial (Soleimani et al, 2018) effects. Additionally, turmeric has been shown to have anti‐inflammatory (Liu et al, 2022), antioxidant (Adab et al, 2019), and anti‐apoptotic (Ibrahim et al, 2019) effects in numerous studies.…”

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confidence: 99%

The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity

Ghasemzadeh Rahbardar,

Hosseinzadeh

2024

Phytotherapy Research

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Ethanol toxicity is a major public health problem that can cause damage to various organs in the body by several mechanisms inducing oxidative stress, inflammation, and apoptosis. Recently, there has been a growing interest in the potential of herbal medicines as therapeutic agents for the prevention and treatment of various disorders. Turmeric (Curcuma longa) extracts and its main components including curcumin have antioxidant, anti‐inflammatory, and anti‐apoptotic properties. This review aims to evaluate the literature on the ameliorative effects of turmeric extracts and their main components on ethanol toxicity. The relevant studies were identified through searches of Google Scholar, PubMed, and Scopus without any time limitation. The underlying mechanisms of turmeric and curcumin were also discussed. The findings suggest that turmeric and curcumin ameliorate ethanol‐induced organ damage by suppressing oxidative stress, inflammation, apoptosis, MAPK activation, TGF‐β/Smad signaling pathway, hyperlipidemia, regulating hepatic enzymes, expression of SREBP‐1c and PPAR‐α. However, the limited clinical evidence suggests that further research is needed to determine the efficacy and safety of turmeric and curcumin in human subjects. In conclusion, the available evidence supports the potential use of turmeric and curcumin as alternative treatments for ethanol toxicity, but further high‐quality studies are needed to firmly establish the clinical efficacy of the plant.

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