Turmeric - A new treatment option for lichen planus: A pilot study

“…The analysed studies show that there are no statistically significant differences between the use of a 5% curcumin oral paste and the use of topical triamcinolone [22]. Singh et al described curcumin as a new safe option for treating OLP, but they found that its effectiveness is lower than that of steroids [55].…”

Section: Curcuminmentioning

confidence: 99%

Clinical Management of Oral Lichen Planus: A Systematic Review

Oberti

Lucchese

Petruzzi

et al. 2019

MRMC

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Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials and Methods:We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non pharmacological intervention). Results:A total of 25 randomized controlled trials were examined and included in this review. Steroids are the most frequently employed drug in the treatment of OLP and their efficacy and safety are demonstrated. Also calcineurin inhibitors and photo-dynamic therapy are used in different studies for OLP management, with positive results. Conclusion:Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations. atrophic-erosive type, but are rarely present in reticular forms [3].It is important to distinguish OLP from oral lichenoid lesions, which can be similar in appearance, but the latter represent a reaction to specific causal factors (e.g. dental materials, traumas, drugs) [5].Managing OLP is aimed at reducing symptoms and the manifestation of lesions, characterized by periods of exacerbation and quiescence. The first-line treatment is represented by the use of topical corticosteroids, although other effective therapies, like photodynamic therapy and the use of calcineurin inhibitors have recently been made available. MATERIALS AND METHODSWe examined the main publications related to OLP management, identified by searching the PubMed electronic database. We used the following search items: oral lichen planus, oral lichen planus management, oral lichen planus treatment, oral lichen planus therapy, randomized trial oral lichen planus, oral lichen planus placebo, oral lichen planus

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“…Singh V et al conducted study on patients of clinically and histological diagnosed oral lichen planus. Turmeric ointment was given to apply topically 2 times a day for 3 months, significant improvement was observed in clinical symptoms [5].…”

Section: Methodsmentioning

confidence: 99%