Turkish propolis supresses MCF-7 cell death induced by homocysteine

Tartik, Musa; Darendelioğlu, Ekrem; Aykutoğlu, Gürkan; Baydaş, Gıyasettin

doi:10.1016/j.biopha.2016.06.013

Cited by 28 publications

(20 citation statements)

References 62 publications

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“…The studies on Vit E demonstrated its protective role against various cancers including colon, prostate and breast cancers. In this research the results supported Recent studies have suggested that dosedependent antioxidants molecules increase LPO levels and oxidative stress and induces apoptosis (Darendelioglu et al, 2016;Tartik et al, 2016). ROS is associated with in loss of mitochondria membranes potentials which are important for opening the mitochondria membranes permeability transition pore (MPTP).…”

Section: Caspase 3 Stainingsupporting

confidence: 83%

SH-SY5Y Nöroblastom Hücrelerinde Beta-karoten, Alfa-tokoferol ve Askorbik asidin Antikanser Etkilerinin Araştırılması

Darendelioğlu

2019

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Neuroblastoma (NB; SH-SY5Y cells) is important characteristic of the most widespread cancer in children after leukaemia and brain cancer. Discovery of new treatment approaches are required for NB disease. Epidemiological studies have demonstrated that different types of antioxidants are associated with decreased cancer and neurodegenerative diseases. Fruits and vegetables have a plenty source of Beta-carotene (BC), Alpha-tocopherol (vit E) and Ascorbic acid (vit C) that have potent free radicals scavenging actions and inhibitory properties to biochemical oxidation. BC, vit E and vit C increase the intracellular reactive oxygen species (ROS) generation and encourages cell apoptosis. It was found that these antioxidants resulted in an increase in the malondialdehyde (MDA) (marker of lipid peroxidation; LPO) and ROS levels at high concentration suggesting it behaves as a prooxidant in this study. The outcomes obviously indicated that studies of SH-SY5Y with dose-dependent BC, vit E and vit C results in oxidative damage through an increase in ROS and LPO generation and the expression of apoptotic marker caspase-3. These consequences find out additional evidences that these antioxidants could be involved in the process of apoptosis for new therapy in NB cells.

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Section: Caspase 3 Stainingsupporting

confidence: 83%

SH-SY5Y Nöroblastom Hücrelerinde Beta-karoten, Alfa-tokoferol ve Askorbik asidin Antikanser Etkilerinin Araştırılması

Darendelioğlu

2019

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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“…Immunohistochemical staining was performed as explained in [19]. The cells containing dark brown nuclei or cytoplasm identified as caspase-3 (+) cells.…”

Section: Immunohistochemical Staining Of Caspase-3mentioning

confidence: 99%

Apoptotic Effects of Beta-Carotene, Alpha-Tocopherol and Ascorbic Acid on Pc-3 Prostate Cancer Cells

Ayna¹

2020

Hacettepe Journal of Biology and Chemistry

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P rostat kanseri (PC), özellikle 50 yaşın üzerindeki erkeklerde kansere bağlı ölümlerin ikinci büyük nedeni olan ve en yaygın olarak teşhis edilen kanser tiplerinden biridir. Bilimsel çalışmalar oksidatif stres ve Reaktif oksijen türlerinin (ROS) prostat kanseri üzerindeki rolünü göstermektedir. ROS, kanserojen moleküller, enfeksiyon, toksi bileşikler gibi homeostaza ve genetik mutasyona neden olabilecek bileşikler tarafından üretilir. Antioksidanlar, ROS'un olumsuz etkilerini in vitro olarak azaltabilir. C vitamini (Askorbik asit, Asc), A vitamini (beta karotenoidler ve retinoidler, β-Crt) ve E vitamini (alfa tokoferol, α-Toc) oksidasyonun önlenmesinde ve vücuttaki serbest radikallerin konsantrasyonunun azaltılmasında önemli rol oynar. Bu çalışmanın amacı, α-Toc, β-Crt ve Asc'nin PC-3 prostat kanseri hücreleri üzerindeki in vitro antikanser etkisini belirlemektir. Bu amaç, hücre çoğalması, ROS ve Lipid Peroksidasyon deneyi, kaspaz-3 ve propidium iyodür boyama deneyleri ile gerçekleştirildi. Bulgular, bu ajanların, prostat kanseri hücrelerinde hücre canlılığını azaltarak ve ROS ve LPO üretimini artırarak proksidan olarak davrandığını göstermektedir. Bu oksidanlar kaspaz-3 (programlı hücre ölümünde rol alan önemli bir enzim) boyamasıyla desteklendiği üzere apoptozu kaspaz-3 enziminin ekspresyonunu artırarak indüklemiştir.

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“…In other countries of Southern European Coast, such as Turkey, chemical composition of propolis has widely investigated by several authors. Quercetin (26), rutin (48), chrysin (2), pinocembrin (3), pinostrobin chalcone (49) and pinobanksin (1) and its derivatives were the most repeated flavonoids found in various simples of propolis from Turkey using different method of analysis such as gas chromatography-mass spectrometry (GC/MS), high-performance liquid chromatography (HPLC) and ultrahigh-performance liquid chromatography with a linear ion trap-high resolution Orbitrap mass spectrometry system (UHPLC-LTQ/orbitrap/MS/MS), [73,[78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95] while Erdogan et al [96] have reported the presence of other flavonoids such as gallocatechin (50), epigallocatechin (51) and myricetin (52) in Anatolian propolis submitted to a pressurized liquid extraction. Other authors did not report the presence of flavonoids in Turkish propolis originating from Hatay, Ankara-Kazan and Mugla-Marmaris, [97 -100] at the same time they declared that terpenes such as αand β-eudesmol, isopimaric acid (42), dehydroabietic acid (53) and abietic acid (54) ( Figure 4) were included in the bioactive compounds of tested propolis samples.…”

Section: Southern European Coastmentioning

confidence: 99%

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

El-Guendouz

Lyoussi

Miguel

2019

Chemistry & Biodiversity

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This review updates the information upon the chemical composition of propolis from all Mediterranean countries as well as their biological properties and applications. The non‐volatile fraction of propolis was characterized by the presence of phenolic acids and their esters and flavonoids. Nevertheless, in some countries, diterpenes were also present: Sicily (Italy), Croatia, Malta, Creta (Greece), Turkey, Cyprus, Egypt, Libya, Algeria and Morocco. The volatile fraction of propolis was characterized by the presence of benzoic acid and its esters, mono‐ and sesquiterpenes, being the oxygenated sesquiterpene β‐eudesmol characteristic of poplar propolis, whereas the hydrocarbon monoterpene α‐pinene has been related with the presence of conifers. Regardless the chemical composition, there are common biological properties attributed to propolis. Owing to these attributes, propolis has been target of study for applications in diverse areas, such as food, medicine and livestock.

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Turkish propolis supresses MCF-7 cell death induced by homocysteine

Cited by 28 publications

References 62 publications

SH-SY5Y Nöroblastom Hücrelerinde Beta-karoten, Alfa-tokoferol ve Askorbik asidin Antikanser Etkilerinin Araştırılması

SH-SY5Y Nöroblastom Hücrelerinde Beta-karoten, Alfa-tokoferol ve Askorbik asidin Antikanser Etkilerinin Araştırılması

Apoptotic Effects of Beta-Carotene, Alpha-Tocopherol and Ascorbic Acid on Pc-3 Prostate Cancer Cells

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

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