Tuning anticancer properties and DNA-binding of Pt(ii) complexes via alteration of nitrogen softness/basicity of tridentate ligands

Abstract

The article illustrates the design flexibility of tridentate ligands and the resultant platinum complexes, highlighting the impact of this design flexibility on the anticancer potential.

Aminoguanidine-based bioactive proligand as AIEE probe for anticancer and anticovid studies

“…When small molecules intercalate into DNA, they separate the base pairs, elongating the DNA and resulting in a significant increase in viscosity. 79 In contrast, groove binding typically make minimal effects on DNA length and therefore have partial or no change in the viscosity of the DNA solution. 77,80 Here, the gradual addition of the compound to CT-DNA resulted in a relatively minor change in viscosity, indicating its role as a groove binder (Fig.…”