Tuning and functionalization of logic gates for time resolved programming of bacterial populations
Leonard E. Bäcker,
Kevin Broux,
Louise Weckx
et al.
Abstract:In order to increase our command over genetically engineered bacterial populations in bioprocessing and therapy, synthetic regulatory circuitry needs to enable the temporal programming of a number of consecutive functional tasks without external interventions. In this context, we have engineered a genetic circuit encoding an autonomous but chemically tunable timer in Escherichia coli, based on the concept of a transcription factor cascade mediated by the cytoplasmic dilution of repressors. As proof-of-concept,… Show more
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