2003
DOI: 10.1007/978-3-540-39903-2_111
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Tuning and Comparing Spatial Normalization Methods

Abstract: Abstract. Spatial normalization is a key process in cross-sectional studies of brain structure and function using MRI, fMRI, PET and other imaging techniques. A wide range of 3D image deformation algorithms have been developed, all of which involve design choices that are subject to debate. Moreover, most have numerical parameters whose value must be specified by the user. This paper proposes a principled method for evaluating design choices and choosing parameter values. This method can also be used to compar… Show more

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Cited by 84 publications
(120 citation statements)
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References 19 publications
(25 reference statements)
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“…The white and gray matter surfaces were fitted using deformable surface-mesh models and nonlinearly aligned toward a standard template surface [Kim et al, 2005;MacDonald et al, 2000;Robbins et al, 2004]. The white and gray matter surfaces were resampled into native space, and cortical thickness was measured in native-space millimeters using the linked distance between the white and pial surfaces at each of 40,962 cortical points throughout the cortex MacDonald et al, 2000].…”
Section: Mri Acquisitionmentioning
confidence: 99%
“…The white and gray matter surfaces were fitted using deformable surface-mesh models and nonlinearly aligned toward a standard template surface [Kim et al, 2005;MacDonald et al, 2000;Robbins et al, 2004]. The white and gray matter surfaces were resampled into native space, and cortical thickness was measured in native-space millimeters using the linked distance between the white and pial surfaces at each of 40,962 cortical points throughout the cortex MacDonald et al, 2000].…”
Section: Mri Acquisitionmentioning
confidence: 99%
“…This algorithm was tuned for chosen parameter values, improving the resulting registrations. Sulcal variability was reduced in all areas of the cortex using optimal parameter values, which was proven by the method of entropy measure (Robbins et al, 2004). Finally, thickness information on each vertex of whole subject was transformed to a template so that the correspondence between subjects at each vertex of the cortical surface model should be assured.…”
Section: Measurement Of Cortical Thickness and Principal Component Anmentioning
confidence: 99%
“…• spatial normalization: defined as an image registration process estimating and applying warp-fields (Robbins et al, 2003);…”
Section: Related Workmentioning
confidence: 99%