Tunicamycin Anticancer Drug May Reliable to Treat Coronavirus Disease-19

Dawood, Ali Adel; Alnori, Haitham

doi:10.3889/oamjms.2020.4954

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…It is understood now that SARS-CoV-2 uses ACE2 receptors to infect lung alveolar epithelial cells [21]. Roughly 17% of protein-protein crosssectional tests were of poor retained resemblance between the NP sequences and the ACE2 receptor.…”

Section: F I G 5 Five Homology Models Of Crystal Structure Docking Np 6vyo-ace2mentioning

confidence: 99%

Molecular Docking of SARS-CoV-2 Nucleocapsid Protein with Angiotensin-Converting Enzyme II

Dawood¹,

Altobje²,

Al-Rrassam³

2021

Mikrobiol. Z.

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SARS-CoV-2 remains life-threatening human pathogen witnessed in the present world. Purpose. The key objective of this research was to incorporate a bioinformatics technique to forecast the molecular docking of the ACE2-associated SARS-CoVs nucleocapsid protein. Methods. Different bioinformatics tools were used in this study in order to compare the chemical structures with their biological behaviour at the levels of atoms and the ligand-binding affinity. This research sought to investigate new data analysis. Results. It was computed the basic 2D structure that occurs in all models, requiring ion ligand binding sites to be predicted. The highlights of the analysis and the associated characteristics are largely responsible for nucleocapsid protein and ACE2 receptor that can be further changed for improved binding and selectivity. Conclusions. The precise functional importance of protein-protein docking cannot be established. But the detection of molecular docking can aid in self-association proteins in our summary, serving as a regulatory switch for the protein’s localization.

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Section: F I G 5 Five Homology Models Of Crystal Structure Docking Np 6vyo-ace2mentioning

confidence: 99%

Molecular Docking of SARS-CoV-2 Nucleocapsid Protein with Angiotensin-Converting Enzyme II

Dawood¹,

Altobje²,

Al-Rrassam³

2021

Mikrobiol. Z.

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“…NP is a highly phosphorylated protein that has several functions. Our study aimed to focus on NP because of the low variable rate with regards to its size advocates its importance to virus survival [14].…”

Section: Resultsmentioning

confidence: 99%

Identification of Cytotoxic T-Cell and B-Cell Epitopes in the Nucleocapsid Phosphoprotein of SARS-COV-2 Using Immunoinformatics

Dawood¹

2021

Mikrobiol. Z.

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Last December, a novel coronavirus emerged in Wuhan city, China. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a high intense acute respiratory syndrome with elevation mortality. Nucleocapsid phosphoprotein (NP) is one of the most structural proteins of the virus. NP possesses active immunogenicity for T-cell response. Because NP considered as a potential vaccine target, our study goal was to identify the cytotoxic T-cell (CTL) and B-cell epitopes inside NP peptides. Methods. We used a series of popular immunoinformatics and algorithm tools such as FASTA-NCBI, CLUSTAL-OMGA, T-COFFEE, SWISS-MODEL, CTLPred and its branches. Results. Homology modeling and alignment of SARS-CoV-2 NP showed high conserved residues compared with related sequences. Different types of the major histocompatibility complex (MHC) alleles were identified, specifically human leukocyte antigens (HLA-A) affinity for NP. We also demonstrate six B-cell epitopes with a high score above the threshold. Conclusions. We recorded high binder HLA-A*02:01 alleles matched between the novel coronavirus SARS-CoV-2 NP and the Bat coronavirus SARS-Bat-CoV NP. Identification of CTL response and B-cell predictions will be helpful in reverse immunogenetic approaches, hence in the strategy process of the plausible design of the vaccine.

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“…Though both have been described as promising pharmaceuticals for the treatment of coronavirus diseases, they possess important toxicity, and, clinical trials associated with new formulations are needed. Tunicamycin inhibits crucial glycoproteins E2, S and M involved in SARS-CoV-2 replication and assembly (Dawood and Alnori, 2020), while plumbagin influences ROS levels, also supposedly impacting on viral replication (Nadhan et al, 2021).…”

Section: Cellular Stressors As Inducers Of Autophagymentioning

confidence: 99%

Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation

Silva

Ribeiro

Silva

et al. 2022

Front. Cell. Infect. Microbiol.

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Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical medical importance are characterized by highly inflammatory pathophysiology, involving severe pulmonary impairment and infection of multiple cell types within the body. Here, we discuss the interplay between coronaviruses and autophagy regarding virus life cycle, cell resistance, and inflammation, highlighting distinct mechanisms by which autophagy restrains inflammatory responses, especially those involved in coronavirus pathogenesis. We also address different autophagy modulators available and the rationale for drug repurposing as an attractive adjunctive therapy. We focused on pharmaceuticals being tested in clinical trials with distinct mechanisms but with autophagy as a common target. These autophagy modulators act in cell resistance to virus infection and immunomodulation, providing a double-strike to prevent or treat severe disease development and death from coronaviruses diseases.

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Tunicamycin Anticancer Drug May Reliable to Treat Coronavirus Disease-19

Cited by 10 publications

References 30 publications

Molecular Docking of SARS-CoV-2 Nucleocapsid Protein with Angiotensin-Converting Enzyme II

Molecular Docking of SARS-CoV-2 Nucleocapsid Protein with Angiotensin-Converting Enzyme II

Identification of Cytotoxic T-Cell and B-Cell Epitopes in the Nucleocapsid Phosphoprotein of SARS-COV-2 Using Immunoinformatics

Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation

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