Tunable dye laser (577 nm) treatment of port wine stains

Morelli, Joseph G.; Tan, Oon Tian; Garden, Jerome M.; Margolis, Randall J.; Seki, Yasuo; Boll, James; Carney, J M; Anderson, R. Rox; Furumoto, H.; Parrish, John A.

doi:10.1002/lsm.1900060119

Cited by 163 publications

(60 citation statements)

References 11 publications

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“…This is called selective pho tothermolysis of blood vessels and has been used successfully in the treatment of port wine stain with the Candela tunable dye laser [7,8], In those studies, all patients had a beneficial response without scarring.…”

Section: Introductionmentioning

confidence: 99%

Tunable Pulsed Dye Laser for the Treatment of Benign Cutaneous Vascular Ectasia

Polla¹,

Tan²,

Garden³

et al. 1987

Dermatology

140

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A tunable pulsed dye laser emitting at 577 nm and 360 μs pulse width was used to treat benign cutaneous vascular ectasias other than port wine stain in 77 patients. Except for leg telangiectasias (34 patients), the overall response was excellent. Forty-two of forty-five patients with hemangiomas, spider nevi, angioma serpiginosum, venous lakes or facial telangiectasias showed excellent results after 1–4 consecutive treatments. Scarring was observed in none of the patients. These results confirm previous data on the use of the tunable dye laser in the treatment of port wine stain, and suggest that 577 nm wavelength and 360 μs pulse width allow the selective photothermolysis of vascular cutaneous ectasias with better clinical results than previously reported.

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Section: Introductionmentioning

confidence: 99%

Tunable Pulsed Dye Laser for the Treatment of Benign Cutaneous Vascular Ectasia

Polla¹,

Tan²,

Garden³

et al. 1987

Dermatology

140

View full text Add to dashboard Cite

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“…Consistent with this theory, ectasia is progressive with age, resulting in lesion darkening from pink to purple. 2 Development of the pulsed dye laser 10,11 and description of the concept of selective photothermolysis 12 significantly improved port wine stain treatment. Yellow light (l 5 585-595 nm) emitted by the pulsed dye laser is preferentially absorbed by hemoglobin (the major chromophore in blood) in the port wine stain vessels and, after being converted to heat, causes thermal damage and thrombosis.…”

Section: Mona M Selim Md Kristen M Kelly Md J Stuart Nelson Mmentioning

confidence: 99%

Confocal Microscopy Study of Nerves and Blood Vessels in Untreated and Treated Port Wine Stains: Preliminary Observations

et al. 2004

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Background and Objective. Vascular ectasia in port wine stain birthmarks (PWS) might result from reduced innervation with loss of autonomic stimulation. We investigated this theory and evaluated nerve and blood vessel density, and mean blood vessel size in untreated and treated PWS skin. Methods. Skin biopsy specimens were obtained from uninvolved skin, untreated PWS, PWS with a good response to laser treatment and PWS with a poor response to laser treatment. Confocal microscopy was performed to determine nerve and blood vessel density, and mean blood vessel size. Results. Nerve density was significantly decreased in all PWS sites compared to uninvolved skin. Mean blood vessel diameter was larger in untreated compared to treated PWS. PWS with a good response to treatment had decreased nerve density but blood vessel density and mean diameter was relatively normal. PWS with a poor response to treatment had decreased nerve density but increased blood vessel density and mean blood vessel diameter compared to normal skin. Conclusion. Nerve density was decreased in all evaluated PWS sites and this may be a factor in lesion pathogenesis. PWS blood vessel size correlated with pulsed dye laser response and may prove to be a useful prognostic indicator of therapeutic outcome.

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“…Due to the high vessel specificity the dye laser at 577 nm is the most promising therapeutical modality. First clinical results have been reported [23],…”

Section: Laser Treatment Of Fort Wine Stainsmentioning

confidence: 99%