2014
DOI: 10.1093/ejcts/ezt649
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Abstract: Masaoka stages III-IV, incomplete resection and non-thymoma histology showed a significant impact in increasing recurrence and in worsening survival. The administration of adjuvant therapy after complete resection is associated with improved survival.

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Cited by 163 publications
(173 citation statements)
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References 25 publications
(26 reference statements)
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“…A recent study based on a large cohort of patients with thymomas revealed that the 10-year OS rate was 0.73 (95% confidence interval 0.69-0.75) (16). The same study reported that Masaoka stages III + IV, incomplete resection and non-thymoma histology (a diagnosis of thymic carcinoma or neuroendocrine thymic tumors) had a significant affect in increasing recurrence and in worsening survival rates of patients (16). Therefore, although the OS rate was relatively high, a cure for advanced thymomas remains a challenge (17,18).…”
Section: Discussionmentioning
confidence: 99%
“…A recent study based on a large cohort of patients with thymomas revealed that the 10-year OS rate was 0.73 (95% confidence interval 0.69-0.75) (16). The same study reported that Masaoka stages III + IV, incomplete resection and non-thymoma histology (a diagnosis of thymic carcinoma or neuroendocrine thymic tumors) had a significant affect in increasing recurrence and in worsening survival rates of patients (16). Therefore, although the OS rate was relatively high, a cure for advanced thymomas remains a challenge (17,18).…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, none of the tested markers correlated with intraoperatively observed macroscopic invasion of surrounding tissue and organs. In addition to the immunohistochemical stainings, a particular set of clinical factors showed significantly worse survival, such as WHO type, Masaoka stage, and metastasis to pleura, lung, lymph nodes and bone, some of which have been investigated in previous studies with comparable results (18,19,(26)(27)(28) .…”
Section: Discussionmentioning
confidence: 99%
“…The interest on surgical management of thymic neoplasms has never been so evident as in the last few years, following the publication of several multi-institutional large series, especially thanks to a formidable scientific effort by the European Society for Thoracic Surgeons (ESTS) and the International Thymic Malignancy Interest Group (ITMIG) (1)(2)(3)(4)(5)(6).…”
mentioning
confidence: 99%
“…The majority of patients present with an early stage disease, confined to the mediastinum and capsulated, usually treated with a surgical excision, with or without postoperative radiotherapy (RT). Tumor clinical stage and a radical resection have been shown to be the most important prognostic factors (1,9,10). Locally advanced TETs (stages III, IVa) occur in 20% to 29% of all surgically treated tumors (1,11), being subject to different range of radical resections (R0) (50-78% in the most recent clinical series), with incomplete ones being significantly more common than in early stage tumors.…”
mentioning
confidence: 99%
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