Tumour proliferation, angiogenesis, and ploidy status in human colon cancer

Cristi, Emanuela

doi:10.1136/jcp.2004.025536

Cited by 20 publications

(19 citation statements)

References 27 publications

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“…Based on previous experience [22][23][24][25][26], staining for VEGF and p53 was defined as positive when >10% of the tumour cells were stained and negative when <10% of the tumour cells were stained.…”

Section: Methodsmentioning

confidence: 99%

Interleukin-17 may be a valuable serum tumor marker in patients with colorectal carcinoma

Radosavljević

Ljujić²,

Jovanović³

et al. 2010

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The promotion of tumor growth is due to a combination of several mechanisms, including angiogenesis and the abundance of cell-derived inflammatory cytokines. The aim of this study was to investigate the serum levels of interleukin 17 (IL-17) and the expression of p53 and Vascular Endothelial Growth Factor (VEGF), in order to determine the relationship between these markers and serum IL-17 levels in patients with colorectal carcinoma.Serum levels of the proinflammatory cytokine IL-17 in patients with colorectal carcinoma (CRC) (n=40) and in a healthy group (n=37) were analysed by ELISA. Surgically resected specimens of 59 colorectal carcinomas were studied by immunohistochemical staining for VEGF and p53.Analyses by ELISA showed significantly higher IL-17 serum levels in patients with colorectal carcinoma than in control subjects (IL-17; mean 128.52±47.62 pg/ml vs. mean 101.91±22.46 pg/ml; p=0.022). We also found an inverse correlation between p53 expression and the level of IL-17 in the serum of patients with CRC. In fact, the serum concentration of IL-17 was significantly higher in patients who did not express p53 (p=0.023). There was no significant correlation between the expression of p53 and VEGF. However, concomitant expression of VEGF and p53 showed a significant correlation with the histological and nuclear grade of the carcinoma.The data presented in our study indicate that IL-17 might act as a valuable tumor marker in patients with CRC and that combined analysis of p53 and VEGF expression might provide additional information about tumor features.

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Section: Methodsmentioning

confidence: 99%

Interleukin-17 may be a valuable serum tumor marker in patients with colorectal carcinoma

Radosavljević

Ljujić²,

Jovanović³

et al. 2010

neo

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“…It is known that angiogenesis is regulated by a balance between stimulator and inhibitor factors (Kondo et al 2000;Takahashi et al 1998Takahashi et al , 2003. Vascular endothelial growth factor (VEGF) is most commonly associated with tumor angiogenesis (Ellis et al 2000;Fontanini et al 2002;La Rosa et al 2003;Takahashi et al 2003;Uehara et al 2004;Cristi et al 2005;Mattioli et al 2007), and has been involved in the proliferation, migration and survival of endothelial cells (Ferrara 1999(Ferrara , 2000Ellis et al 2000;Scoazec 2000;Lappi-Blanco et al 2002;Cristi et al 2005), the induction of fenestrations and increase of the cell permeability (Ferrara 1999(Ferrara , 2000Scoazec 2000).…”

Section: Introductionmentioning

confidence: 98%

Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas

Montero

Abreu

Tonino

2007

J Cancer Res Clin Oncol

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“…Several studies have noted that MVD and expression of VEGF correlates with stage of disease and histological grade of tumor [6,8,9].…”

Section: Journal Of Adenocarcinoma Issn 2572-309xmentioning

confidence: 99%

Correlation of Vascular Endothelial Growth Factor Expression and Neovascularization with Colorectal Carcinoma: A Pilot Study

Mohamed¹,

All²,

Kamel³

et al. 2016

J Adenocarcinoma

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Background: In Egypt, there is an increasing incidence of colorectal cancer (CRC), especially among patients under 40 years of age, affecting a very important age group in our community. The basic pathogenic step in the process of tumor growth, invasion and metastasis is tumor induced angiogenesis. The aim of this study was to evaluate the angiogenesis in colorectal carcinoma by detect the expression of VEGF vascular endothelial growth factor and micro vascular density (MVD) determination with IHC (immunohistochemistry) method and to determine if and how angiogenesis correlates with clinicopathologic parameters. Methods and findings:Sixty five archival, paraffin embedded tissue samples of colorectal carcinoma from Pathology Lab of Suez Canal University Teaching Hospital (Egypt) with complete follow-up files in Oncology Unit from. VEGF and micro vessels were identified immunohistochemically, using monoclonal VEGF antibody and CD34 antibody, respectively. VEGF IHC expression was positive in 94.7% of cases and MVD ranged from 9 to 42 mean 24.55 ± 13.79. A significant positive relation was found between VEGF expression; and histological type, tumor grade, lymph node (LN) involvement, UICC TNM classification, perineural and lympho-vascular invasions (p<0.05). A significant positive relation was found between VEGF expression and MVD (p<0.001). There is a significant correlation has been found between MVD and size of the tumor, histological subtype, tumor grade, LN involvement, UICC TNM classification, vascular and perineural invasion and survival (p<0.05). Conclusions:This study has highlighted the prognostic significance of VEGF and MVD to predict survival in CRC patients, as well as some of traditional prognostic factors as tumor histologic type, tumor size, tumor grade, LN involvement, tumor stage and lympho-vascular and perineural invasion to identify patients at high risk for relapse who may benefit from adjuvant treatment including new therapeutic strategies in the future.

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Tumour proliferation, angiogenesis, and ploidy status in human colon cancer

Cited by 20 publications

References 27 publications

Interleukin-17 may be a valuable serum tumor marker in patients with colorectal carcinoma

Interleukin-17 may be a valuable serum tumor marker in patients with colorectal carcinoma

Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas

Correlation of Vascular Endothelial Growth Factor Expression and Neovascularization with Colorectal Carcinoma: A Pilot Study

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