2010
DOI: 10.1186/1471-2407-10-323
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Abstract: BackgroundThe role of TNFα in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function.MethodsThis study used immunohistochemistry to investigate the expression of TNFα in the tumour islets and stroma with respect to survival in 133 patients with surgically resected NSCLC.ResultsTNFα expression was increased in the tumour islets of patients with above median survival (AMS) compared to those with below media…

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