Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation

Unitt, Esther; Marshall, Aileen; Gelson, William; Rushbrook, Simon; Davies, Susan; Vowler, Sarah L.; Morris, Lydia; Alexander, Graeme

doi:10.1016/j.jhep.2005.12.027

Cited by 231 publications

(183 citation statements)

References 23 publications

(30 reference statements)

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“…Some publications even found that waiting time could be used as an important selection criterion (known as the "test of time") (19)(20)(21). Together with other indicators of tumor biology, such dynamic selection criteria may supersede the current criteria, which are based solely on tumor burden (21)(22)(23). This analysis also investigated the morbidity and mortality rates for both procedures.…”

Section: Discussionmentioning

confidence: 99%

Resection or Transplant in Early Hepatocellular Carcinoma

Schoenberg¹,

Bucher

Vater

et al. 2017

Deutsches Ärzteblatt International

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SUMMARYBackground: Hepatocellular carcinoma (HCC) has an incidence of 5-10 per 100 000 persons per year in the Western world. In 20% of cases, surgical liver resection (LR) or liver transplantation (LT) can be performed. LT results in longer survival, as it involves resection not only of the tumor, but of precancerous tissue as well. The optimal allocation of donor organs depends on the identification of patients for whom LR is adequate treatment. In this meta-analysis, we compare LT and LR for patients with early HCC and wellcompensated cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Resection or Transplant in Early Hepatocellular Carcinoma

Schoenberg¹,

Bucher

Vater

et al. 2017

Deutsches Ärzteblatt International

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“…The infiltration of CD4+ T-cells could be a sign of tumor adaptation known as enhancement [19] . Unitt et al [20,21] indicated that lymphocytic infiltration of the tumor and a high CD4+/CD8+ T cell ratio were associated with a reduced risk of tumor recurrence after liver transplantation for hepatocellular carcinoma. This ratio was beneficial in hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma

Kasper¹,

Drebber²,

Stippel³

et al. 2009

WJG

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AIM:To investigate the role of tumor infiltrating lymphocytes (TIL) in primary hepatocellular and cholangiolar carcinomas of the liver. METHODS:Immunohistochemical analysis was performed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-fixed and paraffin-embedded tissue of 35 liver resection specimens of hepatocellular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface. RESULTS:All hepatocellular carcinomas showed infiltration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power fields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION:Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells independent of histogenetic origin. Different functions of lymphocytes in these regions seem possible.

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“…55,56 The relatively low number of Th1-type CD4 1 T cells with reversed CD4/CD8 ratios in the deceased group in our study supports this hypothesis. Unitt et al 57 observed that a high CD4 1 /CD8 1 T-cell ratio is associated with a reduced risk of tumor recurrence after liver transplantation in hepatocellular carcinoma. Our results obviously reflect the cancerous environment per se and demonstrate that the analysis of the functional phenotypes of TILs 'in situ' may more precisely describe the tumor milieu.…”

Section: Comparative Numbers Of Cd4mentioning

confidence: 99%

A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4+FOXP3+ regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix

et al. 2010

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In this study, 40 biopsy samples collected from cervical cancer patients at the First Affiliated Hospital of Xi'an Jiaotong University, China, were retrospectively assessed using immunohistochemistry for CD4 1 and CD8 1 tumor-infiltrating lymphocytes (TILs) and were analyzed for the expression of FOXP3, OX40, granzyme B (GrB) and perforin (Prf). The proliferating index of the TILs was determined by assessing Ki67 expression. We determined the prognostic value of low and high numbers of TILs on survival by performing KaplanMeier analysis using median values as the cut-off points. Except for the number of CD4 1 FOXP3 1 regulatory T cells (Tregs) and the CD4/ CD8 ratio, none of the CD4 1 , CD8 1 , OX40 1 , GrB 1 or Prf 1 TILs were associated with the overall 5-year survival rate. The 5-year survival rate was significantly lower in patients who had a high percentage of Tregs as compared with the those who had a lower percentage (35.3% versus 88.9%, P50.001), while the 5-year survival rate was significantly higher in patients with a high CD4/CD8 ratio as compared with patients who had a low CD4/CD8 ratio (82.4% versus 44.4%, P50.029). When we considered the deaths and surviving cases as separate groups, we found that both the number of CD4 1 T cells and the CD4/CD8 ratio were significantly lower in patients who died as compared with those who survived (26.33611.80 versus 47.79638.18, P50.023 and 0.6060.25 versus 1.1761.02, P50.019, respectively). In conclusion, decreased proportions of tumor-infiltrating CD4 1 T cells with high percentages of Tregs and reversed CD4/CD8 ratios were significantly associated with the clinical outcome of patients with cervical carcinoma.

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Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation

Cited by 231 publications

References 23 publications

Resection or Transplant in Early Hepatocellular Carcinoma

Resection or Transplant in Early Hepatocellular Carcinoma

Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma

A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4+FOXP3+ regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix

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