Tumorigenicity study of disodium glycyrrhizinate administered orally to mice

Inhibitory effect of 18β-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice

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Inhibitory effect of 18β-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice

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The synergistic anti-asthmatic effects of glycyrrhizin and salbutamol

“…Therefore, discovery of non-steroidal drugs that can be administered longterm without adverse effects is imperative. GL, a natural compound, does not provide any evidence of chronic toxicity or tumorigenicity with long-term daily administration in mice [23] , nor is it teratogenic in rats [24] . The acceptable daily GL intake is reported to be 0.015-0.229 mg/kg body weight per day [25] .…”

Ability of 13 chemical agents used in dental practice to induce sister-chromatid exchanges in Syrian hamster embryo cells

“…Erythrosine B is not carcinogenic in mice and rats. 29,30 Oral administration of erythrosine B results in DNA damage in specific organs of mice, as detected by an in vivo comet assay. 31 However, at the concentrations used in the present study, erythrosine B exhibits negative responses for cell transformation, 13 UDS, 11 and chromosome aberrations (Hagiwara et al unpublished data) in SHE cells.…”

Inhibitory effect of 18β-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice

“……”

“……”

The synergistic anti-asthmatic effects of glycyrrhizin and salbutamol

“…Therefore, discovery of non-steroidal drugs that can be administered longterm without adverse effects is imperative. GL, a natural compound, does not provide any evidence of chronic toxicity or tumorigenicity with long-term daily administration in mice [23] , nor is it teratogenic in rats [24] . The acceptable daily GL intake is reported to be 0.015-0.229 mg/kg body weight per day [25] .…”

Ability of 13 chemical agents used in dental practice to induce sister-chromatid exchanges in Syrian hamster embryo cells

“…Erythrosine B is not carcinogenic in mice and rats. 29,30 Oral administration of erythrosine B results in DNA damage in specific organs of mice, as detected by an in vivo comet assay. 31 However, at the concentrations used in the present study, erythrosine B exhibits negative responses for cell transformation, 13 UDS, 11 and chromosome aberrations (Hagiwara et al unpublished data) in SHE cells.…”

Inhibitory effect of 18β-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice

“……”

“……”

The synergistic anti-asthmatic effects of glycyrrhizin and salbutamol

“…Therefore, discovery of non-steroidal drugs that can be administered longterm without adverse effects is imperative. GL, a natural compound, does not provide any evidence of chronic toxicity or tumorigenicity with long-term daily administration in mice [23] , nor is it teratogenic in rats [24] . The acceptable daily GL intake is reported to be 0.015-0.229 mg/kg body weight per day [25] .…”

Ability of 13 chemical agents used in dental practice to induce sister-chromatid exchanges in Syrian hamster embryo cells

“…Erythrosine B is not carcinogenic in mice and rats. 29,30 Oral administration of erythrosine B results in DNA damage in specific organs of mice, as detected by an in vivo comet assay. 31 However, at the concentrations used in the present study, erythrosine B exhibits negative responses for cell transformation, 13 UDS, 11 and chromosome aberrations (Hagiwara et al unpublished data) in SHE cells.…”