Tumor Venéreo Transmissível (Tvt): Estudo Retrospectivo De 144 Casos .

Huppes, Rafael; Silva, C. G; Uscátegui, Ricardo Andrés Ramírez; Nardi, Andrigo B. De; Souza, Fernando Wiecheteck de; Costa, Mirela Tinucci; Amorim, Renée Laufer; Pazzini, Josiane Morais; Faria, João Bosco

doi:10.15361/2175-0106.2014v30n1p13-18

Cited by 23 publications

(38 citation statements)

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“…During the anamnesis, it has been informed that 2 of the dogs cited in this report had access to the streets without supervision of the owners, and they are likely to have contracted cTVT on one of those occasions. The animal´s care style acts as a risk factor for the development of neoplasia, and dogs that have freely streets access are more exposed to contact with wandering dogs, which are the usual transmission agents of neoplasia [7]. Regarding the second animal reported, the close contact with another female dog, who had compatible vaginal cTVT alterations was probably the factor that determined the transmission.…”

Section: Discussionmentioning

confidence: 96%

“…The cTVT is a neoplasia that affects mainly the external genital region, but can be found in extragenitals organs as nasal, oral and ocular mucosa [2,9,10,15]. It has a cosmopolitan distribution [14] with a higher incidence in dogs that live on the streets or have access to the streets without supervision [7]. Metastasis are uncommon, occurring on average in 5% of cases [14].…”

Section: Introductionmentioning

confidence: 99%

“…Macroscopically it presents as simple or multiple nodules with cauliflower-like appearance, friable and intense reddish color [7,12,14,15]. Microscopically presents round cells with delimited cytoplasmic borders, oval and often eccentric nuclei, granular chromatin and prominent nucleoli [1].…”

Section: Introductionmentioning

confidence: 99%

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Three Cases of Exclusively Extragenital Canine Transmissible Venereal Tumor (cTVT)

Veloso

Oliveira

Andrade

et al. 2018

Acta Scientiae. Vet.

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Background: Canine Transmissible Venereal Tumor (cTVT) is a neoplasia that affects mainly the genital organs of dogs, but can rich extragenital sites as well. It´s a tumor characterized microscopically by the presence of vacuolized round cells. Transmission occurs by implantation of these cells in non-affected tissues and the treatment is based on vincristine chemotherapy.Cases: Case 1. A 5-year-old intact male Poodle, presenting an increase volume of nasal plane came for veterinary care at a private veterinary clinic. The animal had bilateral bloody nasal secretion and dyspnea. The external genitalia had no alterations. The cytological evaluation confirmed cTVT. Treatment with vincristine sulfate weekly showed a rapid responsewith improvement of the respiratory condition, total remission of the mass and absence of neoplastic cells in cytology. Case 2. A 5-year-old mixed-breed canine bitch, weighing 6.7 kg, was brought to the State University of Santa Cruz Veterinary Hospital (UESC-VH), showing an increase volume in the nasal plan region, with complaints about sneezing, nasal bleeding,respiratory distress with approximately 4 months of evolution. The owner informed that the mother of these female dog, that lived in the same environment, died a month before the beginning of clinical signs of the bitch of this case, and showed a reddish vaginal mass with intense bleeding. Intranasal exfoliative cytology showed moderately cellular sample compatible with cTVT. The treatment with vincristine sulphate for 6 weeks, showed completely remission of all clinical signs. Case 3. A 3-year-old mixed-breed male dog was brought to the UESC-VH with a reddish, friable mass located in the left eye. The citology confirmed the clinical suspicion of cTVT. After six weekly sessions of chemotherapy with vincristine sulfate, the tumor regressed and a new cytological evaluation was performed, without visible of tumor cells. By the end of the treatment, the dog was diagnosed with phitisis bulbi, and one year later, due to recurrent ulcerative keratitis, the enucleation was performed and the histopathological examination of the eye did not identify the presence of tumor cells.Discussion: Two of the dogs cited in this report had freely streets access, without supervision of the owners, and they are likely to have contracted cTVT on one of those occasions. The animal’s care style acts as a risk factor for the development of neoplasia. Regarding the third animal, the close contact with another female dog, who had compatible vaginal cTVTclinical signs was probably the factor that determined the transmission. None of the animals cited in this report had lesions on their external genitalia. The extragenital presentation may be attributed to the social behavior of licking and sniffing the genitalia of carrier animals, which may lead to the natural implantation of the viable cells of the cTVT into the ocular and nasal mucosa. About the clinical signs manifested, in the cases of involvement of the nasal structures, the main signs described in literature are bloody nasal secretion, sneezing, dyspnea and increased nasal plane volume, and are similar to those observed in the animals cited in this report. In the case of ocular cTVT, the increase volume with impairment and deformity of all ocular structures, as well as pain and pruritus corroborate with the clinical findings observed in the literature. The cytopathological test was the diagnostic tool used in all cases cited in this report and the cytopathological findings corroborates with those described in the literature. Vincristine sulfate is the drug of choice for the treatment of cTVT cases, and in the dogs of this report, this drug was successfully used leading to complete remission of lesions and clinical signs, as observed in other studies.Keywords: nasal mucosa, ocular mucosa, venereal disease, round cells.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Three Cases of Exclusively Extragenital Canine Transmissible Venereal Tumor (cTVT)

Veloso

Oliveira

Andrade

et al. 2018

Acta Scientiae. Vet.

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“…This lesion is a transplantable neoplasm of round cells that is disseminated in the population mainly through sexual contact. Huppes et al (2014) revealed that 59% of dogs diagnosed with TVT were of the mixed breed, females were more affected than males, and dogs within the 2-8 age group were more frequently affected. These results are similar to those of the present study, since 80.6% (121/150) were crossbred female dogs with a mean age of 5.4 ± 2.4 years; similar findings were described by Amaral et al (2004) and Tinucci-Costa (2009).…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of reproductive disorders in female dogs from the city of Uberlândia, Minas Gerais, Brazil

Costa

Silva

Santos

et al. 2019

SCA

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Diseases of the reproductive system are common in both sexes in the most varied of species. In female dog, these diseases produce different degrees of morbidity and mortality and are influenced by environmental conditions, reproductive history, and previous drug treatments. Reproductive disease may have different consequences, ranging from the absence of clinical signs to the impairment of fertility. The objective of this study was to determine the causes of reproductive diseases in female dogs admitted to the Veterinary Hospital, Federal University of Uberlândia, during a six-year period (2012-2017) and to identify the most frequently occurring diseases. Information relative to the species, age, breed, and sex of 32,944 were obtained for animals. Of these, 16,480 were female dogs and 1,185 were diagnosed with alterations to the reproductive system. The animals were divided into four groups according to age (puppies, young adults, adults, and old) and disease of the reproductive system (Group 1 - vaginal and vulvar alterations; Group 2 - alterations to the estrous cycle, ovary, and uterus; Group 3 - alterations to the gestational period and parturition). The highest occurrence of diagnoses (47%) was recorded in young adult female dogs (1 to 5 years old). The most frequent alterations in female dogs were pyometra (48.8%), dystocia (13.6%), and transmissible venereal tumor (TVT) (12.6%). Crossbred dogs were the most affected with alterations to the reproductive system, representing 60% of all the female dogs diagnosed with any pathologic alteration. In conclusion, a 7.2% occurrence of reproductive disorders shows the relevance of these diseases in small animals and suggests that new methods are needed for the prevention, early diagnosis, and treatment of these disorders.

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“…Porém é importante ressaltar que a população canina brasileira, mais especificamente a teresinense, não é submetida a rigoroso controle epidemiológico, contribuindo para proliferação da doença. O desenvolvimento de lesões extragenitais na maioria das vezes, Segundo Huppes et al (2014) ocorre devido ao ato social dos cães de lamber e farejar, principalmente os genitais, provocando atrito de tecidos, facilitando a implantação de células neoplásicas em novos sítios e, conforme observado neste estudo, onde houve comprometimento nasal.…”

Section: Discussionunclassified

Tumor venéreo transmisible nasal en canino: Reporte de un caso

Pereira¹,

Silva²,

Brito³

et al. 2017

Pubvet

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RESUMO.O tumor venéreo transmissível é uma enfermidade que se apresenta principalmente relacionado ao aparelho genital externo de machos e fêmeas, porém é encontrado na forma extragenital no aparelho respiratório e tecido subcutâneo. Sua transmissão ocorre quando células tumorais e/ou neoplásicas são implantadas mecanicamente, através de montas naturais e também por lambedura excessiva da área genital, podendo ocasionar lesões em nariz, boca, cavidade oral e até mesmo na pele. É um dos tumores de maior incidência na espécie canina, apresentando uma predominância maior em animais jovens, errantes, e sexualmente ativos. No tratamento do tumor venéreo transmissível canino ficam preconizadas a cirurgia, a quimioterapia e a radioterapia. O prognóstico para a remissão total do tumor é bom, a menos que se encontre presente um envolvimento metastático do sistema nervoso central ou dos olhos. Palavras chave: Canino, doença transmissível, neoplásiaNasal transmissible venereal tumor in dog: Case report ABSTRACT. Transmissible venereal tumor is a disease that is mainly related to the external genital tract of males and females, but is found in extragenital form in the respiratory tract and subcutaneous tissue. Its transmission occurs when tumor and / or neoplastic cells are implanted mechanically, through natural mounts and also by excessive licking of the genital area, which can cause lesions in the nose, mouth, oral cavity and even in the skin. It is one of the tumors of higher incidence in the canine species, presenting a greater predominance in young, wandering, and sexually active animals. In the treatment of transmissible venereal tumor, surgery, chemotherapy and radiotherapy are recommended. The prognosis for total tumor remission is good unless metastatic involvement of the Central Nervous System or eyes is present. Key words: Canine, communicable disease, neoplasticTumor venéreo transmisible nasal en canino: Reporte de un caso RESUMEN. El tumor venéreo transmisible es una enfermedad que se presenta principalmente relacionado a los órganos genitales externos de machos y hembras, sin embargo se encuentra en la forma extragenital en las vías respiratorias y el tejido subcutáneo. Su transmisión se produce cuando las células tumorales y/o neoplásico son inplantadas mecánicamente, a través de montas naturales y también por lamido excesivo de la zona genital, puediendo causar lesiones en la nariz, boca, cavidad oral, e incluso la

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Tumor Venéreo Transmissível (Tvt): Estudo Retrospectivo De 144 Casos .

Cited by 23 publications

References 3 publications

Three Cases of Exclusively Extragenital Canine Transmissible Venereal Tumor (cTVT)

Three Cases of Exclusively Extragenital Canine Transmissible Venereal Tumor (cTVT)

A retrospective study of reproductive disorders in female dogs from the city of Uberlândia, Minas Gerais, Brazil

Tumor venéreo transmisible nasal en canino: Reporte de un caso

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