Tumor treating fields for glioblastoma: Review

Abstract

Tumor treating fields (TTF) is delivered with an original device causing antimitotic activity in tumor cells of glioblastoma patients. Low intensity and intermediate frequency alternating electric fields are effective over metaphase. Tumor treating fields is a novel modality approved by FDA (Federal Drug Association) for newly diagnosed and also recurrent glioblastoma. Frequency of 200 kHz is given with transducer applied on scalp of patient. Phase 3 trial showed the efficacy of this modality alone equivalent compared to chemotherapy. Skin toxicity is the major side effect of this therapy. TTF is now used in recurrent glioblastoma but future perspective shows that this unique modality can be delivered in different solid tumors.