Tumor-targeted supramolecular catalytic nanoreactor for synergistic chemo/chemodynamic therapy via oxidative stress amplification and cascaded Fenton reaction

Xu, Xiaoyu; Zeng, Zishan; Chen, Jie; Huang, Binyao; Guan, Zilin; Huang, Yanjuan; Huang, Zeqian; Zhao, Chunshun

doi:10.1016/j.cej.2020.124628

Cited by 90 publications

(39 citation statements)

References 54 publications

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“…The oxidation properties of Fc were investigated. Given •OH production in the Fenton reaction triggered by the oxidation of Fc, degradation of MB after capture of •OH was utilized to characterize the H 2 O 2 -triggered oxidation of Fc [ 67 ]. The results showed that degradation of MB was H 2 O 2 concentration-dependent and suggested that Fc was promptly oxidized by 1 mM of H 2 O 2 ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

Zhang

Zhou

et al. 2023

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

Zhang

Zhou

et al. 2023

Bioactive Materials

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“… In comparison with the conventional therapeutic approaches, CDT shows several unique merits, including endogenous stimulus activation, high tumor specificity, and capability for tumor microenvironment (TME) regulation . CDT based on Fenton reaction can be activated by endogenous stimulus, which could simplify the operational procedure and address the concerns of deep penetration. , Additionally, the Fenton reaction is prone to be initiated under TME, which comprises an abundance of hydrogen ions, lactic acid, and H 2 O 2 . − With the inherent TME-specific targeting characteristics, CDT could achieve significant tumor regression while minimizing nonspecific damage to the normal tissues. − …”

Section: Introductionmentioning

confidence: 99%

Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer

Liu

Jin

Liu

et al. 2020

ACS Biomater. Sci. Eng.

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Chemodynamic therapy (CDT) has aroused extensive attention for cancer treatment in the last five years, as it could suppress tumor progression through in situ detrimental oxidative stress of the tumor cells via the Fenton reaction. Under a tumor acidic microenvironment, the Fenton reaction can be initiated for disproportioning endogenous hydrogen peroxide into highly toxic hydroxyl radical. Taking advantage of the highly tumor-specific therapy modality, various Fenton nanocatalysts have been developed for CDT. In particular, iron-containing Fenton nanocatalysts with minimal cytotoxicity exhibit great promise for clinical translation. In this review, we summarize the recent progress of CDT based on iron-containing nanomaterials, including iron oxide nanoparticles, glassy iron nanoclusters, ferrocene nanoparticles, metal polyphenol networks, metal–organic frameworks, etc. We also discuss the challenges and perspectives for promoting CDT by rational design of iron-containing nanomaterials, highlighting their potential for precise cancer therapy.

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“…CA can promote intracellular ROS generation mainly in mitochondria and amplify oxidative stress to induce ROS-mediated mitochondrial dysfunction and caspase activation for cancer cells apoptosis 34 , 35 . Furthermore, CA has been confirmed to effectively elevate intracellular H 2 O 2 level, and induce massive •OH generation through Fenton reaction for enhancing routine CDT efficacy 36 , 37 . CDT is an emerging anticancer treatment utilizing iron-mediated Fenton reactions to convert intracellular mild H 2 O 2 into highly cytotoxic •OH for cellular damage 38 , 39 .…”

Section: Introductionmentioning

confidence: 98%

Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy

Xu¹,

Huang²,

Zeng³

et al. 2020

Theranostics

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Cancer cells immersed in inherent oxidative stress are more vulnerable to exogenous oxidative damages than normal cells. Reactive oxygen species (ROS)-mediated oxidation therapy preferentially aggravating tumor oxidative stress to disrupt redox homeostasis, has emerged as an effective and specific anticancer treatment. Herein, following an ingenious strategy of “broaden sources and reduce expenditure”, we designed a versatile tumor-specific oxidative stress nanoamplifier enabling economized photodynamic therapy (PDT), to achieve synergistic oxidative stress explosion for superior oxidation therapy. Methods: Cinnamaldehyde (CA) as a therapeutic ROS generator was first conjugated to hyaluronic acid (HA) through acid-labile hydrazone bond to synthesize tailored amphiphilic HA@CA conjugates, which could surprisingly self-assemble into uniform nanofibers in aqueous media. Photosensitizer protoporphyrin (PpIX) was efficiently encapsulated into HA@CA nanofibers and transformed HA@CA nanofibers to final spherical HA@CAP. Results: With beneficial pH-responsiveness and morphology transformation, improved bioavailability and selective tumor accumulation, HA@CAP combining ROS-based dual chemo/photodynamic treatment modalities could induce cytotoxic ROS generation in a two-pronged approach to amplify tumor oxidative stress, termed “broaden sources”. Moreover, utilizing CA-induced H 2 O 2 production and cascaded Fenton reaction in mitochondria to consume intracellular overloaded Fe(II), HA@CAP could skillfully block endogenic heme biosynthesis pathway on site to restrain undesired elimination of PpIX for economized PDT, termed “reduce expenditure”. Both in vitro and in vivo results demonstrated the superior antitumor performance of HA@CAP. Conclusion: This study offered an inspiring strategy of “broaden sources and reduce expenditure” to specifically boost tumor oxidative stress for reinforced oxidation therapy.

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Tumor-targeted supramolecular catalytic nanoreactor for synergistic chemo/chemodynamic therapy via oxidative stress amplification and cascaded Fenton reaction

Cited by 90 publications

References 54 publications

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer

Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy

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