Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties

Zhen-lu, Huang; Cheng, Yue; Chiu, Pei-Chen; Cheung, Florence; Nicholls, John M.; Kwong, Dora L.W.; Lee, A W M; Zabarovsky, Eugene R.; Stanbridge, Eric J.; Lung, Hong Lok; Lung, ML

doi:10.1038/onc.2011.529

Cited by 61 publications

(47 citation statements)

References 40 publications

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“…To examine the subcellular localization of β-catenin, HeLa cells were seeded in 10 cm plates (5 × 10 5 ) and transfected with control-or CD44-siRNA. Seventy-two hours later, cells were treated for 6 h with Wnt3a-CM or Co-CM and subjected to subcellular fractionation as described in Huang et al 66 The membrane and cytosolic fraction were subjected to western blotting analysis using antibodies against CD44 (Hermes-3) and total β-catenin. Antibodies against Erk were used as control for the cytosolic fraction.…”

Section: Methodsmentioning

confidence: 99%

CD44 functions in Wnt signaling by regulating LRP6 localization and activation

et al. 2014

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Wnt reception at the membrane is complex and not fully understood. CD44 is a major Wnt target gene in the intestine and is essential for Wnt-induced tumor progression in colorectal cancer. Here we show that CD44 acts as a positive regulator of the Wnt receptor complex. Downregulation of CD44 expression decreases, whereas CD44 overexpression increases Wnt activity in a concentration-dependent manner. Epistasis experiments place CD44 function at the level of the Wnt receptor LRP6. Mechanistically, CD44 physically associates with LRP6 upon Wnt treatment and modulates LRP6 membrane localization. Moreover, CD44 regulates Wnt signaling in the developing brain of Xenopus laevis embryos as shown by a decreased expression of Wnt targets tcf-4 and en-2 in CD44 morphants.

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Section: Methodsmentioning

confidence: 99%

CD44 functions in Wnt signaling by regulating LRP6 localization and activation

et al. 2014

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“…Lost or diminished CRYAB expression is recognized as a prognostic marker of such cancers as prostate and HNC. 61,62 Research by Su et al 62 showed that allele G of CRYAB C-802G is correlated to breast cancer risk, and could be useful as a clinical marker for its early detection. Compared with the models described by Vineis et al…”

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confidence: 99%

Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5years

et al. 2014

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El Repositorio Digital de la Universidad Nacional de Córdoba (RDU), es un espacio donde se almacena, organiza, preserva, prov ee acceso libre y procura dar visibilidad a nivel nacional e internacional, a la producción científica, académica y cultural en formato digital , generada por los integrantes de la comunidad universitaria. RISK GENES IN HEAD AND NECK CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF LAST 5 YEARSBrunotto Cita del documento:Brunotto, M, Zarate, A.M, Bono, A, Barra, J.L, Berra, S. Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years. Oral Oncol. 2014;3(50): 178-188. Disponible en: https://rdu.unc.edu.ar/handle/11086/5502Este documento está disponible para su consulta y descarga en RDU (Repositorio Digital de la Universidad Nacional de Córdoba) . El mismo almacena, organiza, preserva, provee acceso libre y da visibilidad a nivel nacional e internacional a la producción científica, académica y cultural en formato digital, generada por los miembros de la Universidad Nacional de Córdoba. Para más información, visite el sitio https://rdu.unc.edu.ar/ Esta iniciativa está a cargo de la OCA (Oficina de Conocimiento Abierto), conjuntamente con la colaboración de la Prosecretaria de Informática de la Universidad Nacional de Córdoba y los Nodos OCA. Para más información, visite el sitio http://oca.unc.edu.ar/ It is known that the apoptotic and proliferation genes are involved in cancer development and these could be useful as a biomarker of this pathology. Systematic reviews and meta-analysis allow stronger and more generalized conclusions for identifying some models of risk markers. These models may help in screening, early diagnosis and/or therapy in the clinic. 2-5In recent decades, there has been increased interest in genetic predisposition studies in complex disease. This has led to the production of an enormous number of epidemiologic papers about the relationship between genetic polymorphism and disease. However, the magnitude of association between specific polymorphism and disease is still not established. The aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates. METHODS Search strategy and selection criteriaThis study was made according to the PRISMA reporting items for systematic reviews and metaanalysis guidelines. We conducted a systematic review and meta-analysis of case-control studies from the MEDLINE, Scopus, Cochrane, and CancerLit databases between January 2007 and January 2013. Language is not restricted. The search strategy included the following keywords 3 (variably combined): "oral cancer", "oral cancer polymorphism", "oncogene", "tumor suppressor gene", "squamous cell carcinoma", "head and neck cancer". Data extractionData was collected of adult patients of both genders, with diagnosis of head and neck carcinoma according to the criteria of ICD-10C00-C14 WHO or another specific source, in whom genetic polymorphisms ...

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“…Overexpression of HspB5 in cell lines of this type of cancer suppressed progression-associated phenotypes such as loss of cell adhesion, invasion and interaction with the tumor microenvironment (Huang et al 2012 ). Similarly, patients with cutaneous squamous cell carcinoma having perineural invasion, which is associated with a poor prognosis, showed lower HspB5 expression compared to patients without perineural invasion (Solares et al 2010 ).…”

Section: Hspb5 Expression In Cancersmentioning

confidence: 97%

Role of Small Heat Shock Protein HspB5 in Cancer

Boelens¹

2015

Heat Shock Proteins

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HspB5, also called αB-crystallin, is a ubiquitous small heat shock protein (sHSP) that is strongly induced by a variety of stresses, but that also functions constitutively in multiple cell types. Extensive research has demonstrated that HspB5 acts as an ATP-independent molecular chaperone by binding unfolding proteins and protecting cells from damage due to irreversible protein aggregation. As a result of its importance in protein homeostasis HspB5 is of signifi cant interest to many areas of cell biology, including the development of cancer. However, the molecular understanding of HspB5's role in cancer is only beginning to emerge. In this chapter an overview is given of data that provide insight into the oncogenic role of HspB5 in human cancer.

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Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties

Cited by 61 publications

References 40 publications

CD44 functions in Wnt signaling by regulating LRP6 localization and activation

CD44 functions in Wnt signaling by regulating LRP6 localization and activation

Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5years

Role of Small Heat Shock Protein HspB5 in Cancer

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