“…Nanoparticles prepared with PLGA are often used as an siRNA delivery system. 18 , 27 , 28 , 29 , 30 , 31 , 32 , 33 When preparing siRNA-incorporated PLGA nanoparticles using the double emulsion method, poly (vinyl alcohol) (PVA) is usually used as the emulsifying agent to create stable and homogenous emulsions. 18 , 27 , 28 , 29 , 30 , 31 , 34 In order to PEGylate the PLGA nanoparticles, copolymers synthesized by conjugating PEG molecules with PLGA or PLA are regularly used.…”