2011
DOI: 10.1038/jid.2011.64
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Abstract: Human adipose tissue-derived mesenchymal stem cells (ASCs) stimulate regeneration of injured tissues by secretion of various cytokines and chemokines. Wound healing is mediated by multiple steps including inflammation, epithelialization, neoangiogenesis, and proliferation. To explore the paracrine functions of ASCs on regeneration of injured tissues, cells were treated with tumor necrosis factor-α (TNF-α), a key inflammatory cytokine, and the effects of TNF-α-conditioned medium (CM) on tissue regeneration were… Show more

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Cited by 161 publications
(123 citation statements)
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“…This macrophage immunophenotype is favorable for wound resolution, as IL-6 is critical for the progression of normal wound healing processes, whereas IL-10, among other factors, downregulates inflammation associated with excessive TNF-␣ and IL-12 expression [24,47]. Similarly, encapsulation of MSCs within a biomatrix that maintains MSC survival and function long-term is expected to reprogram infiltrating macrophages toward an anti-inflammatory phenotype that promotes overall wound healing processes in vivo [48,49]. The initial burst of TNF-␣ expression (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…This macrophage immunophenotype is favorable for wound resolution, as IL-6 is critical for the progression of normal wound healing processes, whereas IL-10, among other factors, downregulates inflammation associated with excessive TNF-␣ and IL-12 expression [24,47]. Similarly, encapsulation of MSCs within a biomatrix that maintains MSC survival and function long-term is expected to reprogram infiltrating macrophages toward an anti-inflammatory phenotype that promotes overall wound healing processes in vivo [48,49]. The initial burst of TNF-␣ expression (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…In this way, inhibition of proliferation and differentiation of leukemia cells is no longer a problem. EGR1 is also important for development of the macrophage lineage (96). It is interesting to note that EGR-1 abrogates the block in M1 terminal differentiation imparted by oncogenic c-Myc or E2F-1, suppressing their leukemia promoting function in nude mice (97).…”
Section: Pathogenesis Mechanism Of Aml By Egr1mentioning
confidence: 99%
“…Those mechanisms include the stimulation of endogenous stem/progenitor cells, cell proliferation, and angiogenesis, as well as the suppression of inflammation and cell death [3]. This paracrine signaling function of MSCs has now been substantiated in several hallmark studies of emerging medical applications for MSCs in areas of wound healing, as well as neurological, cardiac, and vessel regeneration: therapeutic improvement was attributed chiefly to the presence of a regenerative secretome rather than to significant direct engraftment and differentiation of MSCs into cells comprising the injured tissue [3][4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…It is plausible that those progenitor cell subpopulations could thus be more therapeutically efficacious than uncommitted, multipotent MSCs (i.e., stem cells) for some translational applications. Recent investigations of the physiological roles of MSCs and their progenitors within the marrow have provided insight into their different possible therapeutic values [5,[13][14][15][16][17]. Literature observations have alluded to a connection between BM-derived MSCs with high osteogenic activity and the capabilities for microenvironmental repair as well as HSC support, both of which critical for BM homeostasis.…”
Section: Introductionmentioning
confidence: 99%