2018
DOI: 10.1080/2162402x.2018.1490854
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible to anti-tumor immunity from weakly immunogenic or inherently immune-resistant tumors would guide development of therapeutic strategies in breast cancer. Genomic, transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) breast cancer cohorts were used to examine statistical assoc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

11
210
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
9
1

Relationship

2
8

Authors

Journals

citations
Cited by 209 publications
(221 citation statements)
references
References 58 publications
11
210
0
Order By: Relevance
“…To test the applicability of the study-derived immune signatures in other cancers, we probed TCGA RNA-Seq data for uterine corpus endometrial cancer (UCEC) and high tumor mutational burden (Hi-TMB) breast cancer (BRCA) patients [24,25]. The patient characteristics for these two cohorts are shown in Table S4.…”
Section: Significance Of Pan-cancer-based Immune Signature In Other Cmentioning
confidence: 99%
“…To test the applicability of the study-derived immune signatures in other cancers, we probed TCGA RNA-Seq data for uterine corpus endometrial cancer (UCEC) and high tumor mutational burden (Hi-TMB) breast cancer (BRCA) patients [24,25]. The patient characteristics for these two cohorts are shown in Table S4.…”
Section: Significance Of Pan-cancer-based Immune Signature In Other Cmentioning
confidence: 99%
“…In BRCA-1/2 mutated ovarian cancers, TMB correlates with improved overall survival [30,31]. In breast cancer patients, tumors with high TMB and favorable immune-infiltrate ("hot tumors") are associated with prolonged survival [32]. Consistently, basal cell carcinoma, which is characterized by very high TMB, presents with slow growth rates and rare metastases.…”
mentioning
confidence: 99%
“…Many previous studies have shown that EMT-related pathways and transcription factors are involved in the regulation of PD-L1. 23,24 It has been reported that ZEB1 can increase PD-L1 expression by activating miRNA-200 in NSCLC and results in a dysfunction of CD8+ T cells, which couples with epithelial-mesenchymal transition (EMT) to increase metastasis. In autochthonous mouse melanoma models, Spranger S. et al demonstrated that tumorintrinsic active β-catenin signaling results in T cell exclusion and resistance to anti-PD-L1/anti-CTLA-4 monoclonal antibody therapy.…”
Section: Discussionmentioning
confidence: 99%