Tumor filoides de la mama

Abstract

Phyllodes tumor of the breastIntroduction: The phyllodes tumor (PT) of the breast is a rare disease of unknown origin. Despite its classification into benign, borderline and malignant, their behavior tends to be uncertain. Because of this, treatment remains controversial. Objective: To describe the management of the FT in breast pathology unit of our hospital and their outcomes. Material and Methods: We retrospectively reviewed the files of the patients with PT, operated in our hospital between 2001 and 2008. We analyzed the clinical characteristics, diagnostic studies, treatment and outcomes. Results: During this period 12 patients were operated. The average age was 42 ± 15.2 years (16-64) and usually the form of presentation was painless palpable nodule. Both mammography and ultrasound were unable to suggest the diagnosis. Eight patients had core biopsy, which revealed the diagnosis of PT in 5, while in the other 3 was fibroadenoma. All patients underwent a partial mastectomy. The biopsy showed six benign, two borderline and two malignant PT. The latter two patients received adjuvant radiotherapy. At the end of this study, 2 patients had relapsed at 12 and 30 months (borderline and benign, respectively). There were no cases of lymphatic or distant metastases. Conclusions: The PT has a low frequency of presentation and preoperative diagnosis is difficult, so we recommend a core biopsy, but it can confuse with fibroadenoma. The management with partial mastectomy and negative borders had a recurrence rate of 18% in this series. ResumenIntroducción: El tumor filoides (TF) de la mama es una patología poco frecuente y origen desconocido. A pesar de su clasificación en benignos, borderline y malignos, su comportamiento tiende a ser incierto. Debido a esto su tratamiento sigue siendo controversial. Objetivo: Describir el manejo del TF en la unidad de Rev.

Phyllodes tumor of the breast: a clinic-pathologic study of 77 cases in a Hispanic cohort

“…The current study with 77 cases, is one of the largest breast mammary PT series reported in Latin America [5][6][7][8] , with a global survival of 94.5% that is similar to that reported in other series found in the world literature 9 ; this survival data was not affected despite the large tumor size of our patients at the moment they received oncological management (60.5% of the patients had tumors larger than five centimeters); however, the radical surgery rate in our cohorts were greater than those reported in other series [10][11][12] Given the infrequency of this type of tumor, epidemiological data is scarce. Berstein et al, 13 in the city of Los Angeles over a 17-year period, the average annual incidence was 2.1 cases per million women; this study reported a high incidence in Latin white women compared to non-Latin white, Asian, and black.…”

Características clínico patológicas, tratamiento y pronóstico de tumor filodes en centros de referencia en Medellín, Colombia

“…El TF tiene apariencia de nódulo de contornos bien definidos, macrolobulado, similar a un fibroadenoma (22) . No es posible discriminar los tipos histológicos a través de hallazgos imagenológicos que permitan su diferenciación (23) . En series de casos publicadas, se ha encontrado que la evaluación con resonancia magnética podría distinguir los TF de histología limítrofe y maligna, identificando en ellas septos con baja señal interna y patrones similares a un sedimento, en las secuencias T2 (24) .…”

Tumor filoide maligno de mama bilateral: relato de caso

“…Ao ultrassom, usualmente é referido como nódulo sólido, lobulado, com contornos bem definidos, podendo estar ou não associado a componentes císticos 4 . Por suas características macroscópicas, margens bem delimitadas sem invasão do tecido mamário (benigno), o principal diagnóstico diferencial do tumor filoide se faz com o fibroadenoma (FA), principalmente em jovem e em tumores de menor porte 5 . Por conta de sua semelhança macroscópica ao FA, a ultrassonografia e a mamografia são consideradas inadequadas para o diagnóstico do TF.…”