Tumor-derived extracellular vesicles in angiogenesis

Song, Wei; Dong, Yan; Wei, Tianshu; Liu, Qiang; Zhou, Xia; Liu, Ju

doi:10.1016/j.biopha.2018.03.148

Cited by 35 publications

(20 citation statements)

References 71 publications

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“…Evidence from preclinical and clinical studies indicates that VEGF is the predominant angiogenic factor in human colon cancer and is associated with formation of metastases and poor prognosis ( 32 ). So far, innumerous models tried to recreate these phenomena ( 30 , 33 , 34 ). For instance, the tube formation assay involves the reorganization of endothelial cells seeded on Matrigel surface to form cords similar to vascular networks.…”

Section: Discussionmentioning

confidence: 99%

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

et al. 2019

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Awareness that traditional two-dimensional (2D) in vitro and nonrepresentative animal models may not completely emulate the 3D hierarchical complexity of tissues and organs is on the rise. Therefore, posterior translation into successful clinical application is compromised. To address this dearth, on-chip biomimetic microenvironments powered by microfluidic technologies are being developed to better capture the complexity of in vivo pathophysiology. Here, we describe a “tumor-on-a-chip” model for assessment of precision nanomedicine delivery on which we validate the efficacy of drug-loaded nanoparticles in a gradient fashion. The model validation was performed by viability studies integrated with live imaging to confirm the dose-response effect of cells exposed to the CMCht/PAMAM nanoparticle gradient. This platform also enables the analysis at the gene expression level, where a down-regulation of all the studied genes (MMP-1, Caspase-3, and Ki-67) was observed. This tumor-on-chip model represents an important development in the use of precision nanomedicine toward personalized treatment.

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Section: Discussionmentioning

confidence: 99%

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

et al. 2019

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“…By secreting EVs, cancer cells may communicate with nearby stromal cells, such as endothelial cells, cancer-associated fibroblasts (CAFs), and by entering into the circulation, they may interact with distant cells. Cancer EVs are able to orchestrate several processes, such as angiogenesis (124), extracellular matrix remodeling (110,125), and induction of epithelial-mesenchymal transition (EMT), promoting tumor aggressiveness, invasiveness, and metastatic potential (48, 54 -56, 111, 142). In turn, tumor stroma cells by secreting EVs may influence tumor progression.…”

Section: Cancer Cell-derived Extracellular Vesicles and Tumor Microenmentioning

confidence: 99%

Role of extracellular vesicles in stem cell biology

Bruno

Chiabotto

Favaro

et al. 2019

American Journal of Physiology-Cell Physiology

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The extracellular vesicles (EVs) are membrane vesicles carrying proteins, nucleic acids, and bioactive lipids of the cell of origin. These vesicles released within the extracellular space and entering into the circulation may transfer their cargo to neighboring or distant cells and induce phenotypical and functional changes that may be relevant in several physiopathological conditions. In an attempt to define the biological properties of EVs, several investigations have focused on their cargo and on the effects elicited in recipient cells. EVs have been involved in modulation of tumor microenvironment and behavior, as well as in the immune and inflammatory response. In the present review, we address the paracrine action of EVs released by stem cells and their potential involvement in the activation of regenerative programs in injured cells.

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“…Under hypoxic conditions, miR-210 has the ability to inhibit ephrin-A3 receptor tyrosine kinase expression [153][154][155]. As a result of this interaction, increased secretion of VEGF occurs, which stimulates the formation of new blood vessels [156,157]. To stimulate VEGF gene expression, exosomal miR-9 contributes indirectly, which activates the JAK-STAT signaling pathway [158][159][160].…”

Section: Exosomesmentioning

confidence: 99%

Important players in carcinogenesis as potential targets in cancer therapy: an update

2020

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The development of cancer is a problem that has accompanied mankind for years. The growing number of cases, emerging drug resistance, and the need to reduce the serious side effects of pharmacotherapy are forcing scientists to better understand the complex mechanisms responsible for the initiation, promotion, and progression of the disease. This paper discusses the modulation of the particular stages of carcinogenesis by selected physiological factors, including: acetylcholine (ACh), peroxisome proliferator-activated receptors (PPAR), fatty acid-binding proteins (FABPs), Bruton's tyrosine kinase (Btk), aquaporins (AQPs), insulin-like growth factor-2 (IGF-2), and exosomes. Understanding their role may contribute to the development of more effective and safer therapies based on new binding sites.

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Tumor-derived extracellular vesicles in angiogenesis

Cited by 35 publications

References 71 publications

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

Role of extracellular vesicles in stem cell biology

Important players in carcinogenesis as potential targets in cancer therapy: an update

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