Tumor Characteristics and Survival Outcome of Endometrial Cancer Arising in Adenomyosis: An Exploratory Analysis

Matsuo, Koji; Moeini, Aida; Machida, Hiroko; Scannell, Christopher A.; Casabar, Jennifer K.; Kakuda, Mamoru; Adachi, Sosuke; Garcia‐Sayre, Jocelyn; Ueda, Yutaka; Roman, Lynda D.

doi:10.1245/s10434-015-4952-y

Cited by 29 publications

(39 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adenomyosis is a frequent finding during the histopathologic evaluation of hysterectomy specimens of patients with endometrial cancer. In previous studies, adenomyosis coexisted with endometrial cancer in 0-70% 14 of cases, which is consistent with the studies we included 6.4-66% of cases. 4,[8][9][10][11][12][15][16][17][18][21][22][23][24] Furthermore, a population-based study comprising 768 patients with adenomyosis alone exhibited a fivefold increased risk of developing endometrial cancer.…”

Section: Discussionsupporting

confidence: 92%

“…[8][9][10][11][12] However, other studies have identified adenomyosis as the precursor of endometrial cancer. [13][14] Conversely, co-existent adenomyosis in endometrial cancer has no impact on survival outcomes according to some studies. [15][16][17][18] Nevertheless, there exists a conflict regarding the influence of adenomyosis on the prognosis of endometrial cancer, with studies reporting conflicting results.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic significance of co‐existent adenomyosis on outcomes and tumor characteristics of endometrial cancer: A meta‐analysis

Duan

Zhang

2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Objective Published data on the impact of co‐existent adenomyosis on the prognosis of patients with endometrial cancer remains elusive, with studies reporting conflicting results. We conducted this meta‐analysis to evaluate the prognostic significance of co‐existent adenomyosis on clinical outcomes and tumor characteristics of endometrial cancer patients. Methods A comprehensive literature review of multiple databases was conducted; quality assessment of eligible studies was performed by the Newcastle‐Ottawa scale (NOS). The outcomes of interest were compared in endometrial cancer patients with or without adenomyosis. Hazards ratios (HR) and Odds ratios (OR) with 95% confidence interval (CI) were calculated as a measure of effects. Results Fourteen retrospective observational studies comprising 1308 endometrial cancer patients with adenomyosis and 3734 patients without adenomyosis were included in this meta‐analysis. Results indicated that endometrial cancer patients with adenomyosis was significantly associated with an increased overall survival rate (HR = 0.51; 95% CI = 0.38–0.69; P < 0.00001), but not with disease‐free survival rate (HR = 0.68; 95% CI = 0.30–1.53; P = 0.35); besides, significantly associated with decreased ratio of deep myometrial invasion (OR = 0.45; 95% CI = 0.33–0.60; P < 0.00001), lymphovascular space invasion (OR = 0.44; 95% CI = 0.29–0.68; P = 0.0002), an increased ratio of histological grade 1 (OR = 1.84; 95% CI = 1.34–2.53; P = 0.0002) and FIGO I‐II (OR = 1.85; 95% CI = 1.49–2.30; P < 0.00001). However, there was no significant difference in pathological type and lymph node metastasis. There was a low to high heterogeneity with I2 ranging from 0 to 67%. Conclusion This meta‐analysis indicated that co‐existent adenomyosis with endometrial cancer is associated with favorable tumor characteristics and could serve as a potential protective factor for the prognosis of endometrial cancer.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Prognostic significance of co‐existent adenomyosis on outcomes and tumor characteristics of endometrial cancer: A meta‐analysis

Duan

Zhang

2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…Although adenomyosis is generally considered a benign condition with no increased risk for developing cancer, the endometrial tissue within the myometrium could develop endometrioid adenocarcinoma, with potentially deep myometrial invasion [30]. Studies have reported that a history of adenomyosis significantly increased the risk of developing endometrial cancer [27,[31][32][33]. In our current study, we also found the odds of women with a history of adenomyosis were around 4 times higher among women with endometrial cancer than the controls.…”

Section: Discussionsupporting

confidence: 66%

Association of benign gynaecological diseases and risk of endometrial and ovarian cancers

Shen¹,

Liu

Lin

et al. 2020

J. Cancer

View full text Add to dashboard Cite

Objective: Gynaecologic benign diseases such uterine fibroids share similar pathogeneses with endometrial and ovarian cancers. Whether a history of uterine fibroids increases the risk of developing endometrial or ovarian cancers is controversial, due to uterine fibroids was self-reported in those studies. Methods: In our current case-control study, 268 women with endometrial cancer and 108 women with ovarian cancer were included. In addition, 500 women without gynaecological cancers were randomly selected as a control group. Uterine fibroids in both groups were clinically diagnosed by pelvic examination and ultrasound. Data on age, parity, gravida, stages of cancers and history of uterine fibroids, endometriosis and adenomyosis were collected from hospital database. Results: After adjusted age and parity, the odds of women with history of uterine fibroids or endometriosis were lower in women with endometrial cancer than controls (odds ratio: 0.148, 95% CI: 0.097, 0.225, or 0.360, 95% CI: 0094, 1.381, respectively). The odds of women with a history of uterine fibroids or endometriosis were lower in women with ovarian cancer than controls (odds ratio: 0.141, 95% CI: 0.085, 0.235, or 1.057, 95% CI: 0.377, 2.963, respectively). However, the odds of women with a history of adenomyosis were higher in women with endometrial or ovarian cancers than controls (odd ratio: 3.757, 95% CI: 1.858, 7.599 or 2.341, 95% CI: 1.086, 5.045, respectively). Conclusion: Our observational data suggested that uterine fibroids or endometriosis may be not associated with the increased risk of developing endometrial or ovarian cancer. However, a history of adenomyosis may do.

show abstract

“…In our patients, EEC-AIA was associated with significantly younger onset ages and better survival than other subtypes, as no recurrence or death occurred in EEC-AIA patients. Although EEC-AIA had similar expression of progesterone and estrogen receptors in our study, in two exploratory analyses utilizing the EEC-AIA from data in the literature and non-EEC-AIA cases from a historical cohort at the studied centers 11,14,19 , EEC-AIA patients were found to be significantly older and less likely to express the estrogen receptor. The reasons behind the differences in the clinicopathological and survival outcomes of EEC-AIA require further clarification.…”

Section: Discussionmentioning

confidence: 38%

“…Since Colman and Rosenthal firstly discovered EC-AIA in 1958 12 , only 46 and 78 cases have been reported by Machida et al 11 and Habiba et al 13 up to 2017, respectively, due to its strict definition. Available evidence for EC-AIA has been limited to case reports and exploratory analyses of the literature 14 . Due to the limited sample size and study design, no valid conclusions about the EC-AIA have been reached or generalized from these studies.…”

mentioning

confidence: 99%

The clinicopathological characteristics and survival outcomes of endometrial carcinoma coexisting with or arising in adenomyosis: A pilot study

Chao

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Little is known about the epidemiological and clinicopathological characteristics of endometrial endometrioid carcinoma (eec) coexisting with or arising in adenomyosis (eec-A or eec-AiA) due to their rarity. this study compared eec-A and eec-AiA with endometrial carcinoma without adenomyosis. Cases of endometrial cancer treated at the study center from June 1, 2010, to June 1, 2017, were reviewed. The epidemiological, clinicopathological characteristics and survival outcomes were compared among three groups of endometrioid subtypes: group A, stage iA endometrial carcinoma patients without coexisting adenomyosis; group B, patients with eec-A; and group c, patients with EEC-AIA. Among the 2080 patients reviewed, groups A, B, and C included 1043, 230 and 28 patients, respectively. Patients in group A and group B had similar clinicopathological and survival outcomes. Patients in group C were significantly younger and had less gravidity and parity than patients in groups A and B. More tumors from group C were grade 1, and they had a smaller maximum diameter and less mismatch repair deficiency than those from groups A and B. After a median follow-up of 57.0 months, the 5-year disease-free survival (DFS) rates of groups A, B and C were 96%, 91% and 100% (p = 0.045), respectively; the 5-year overall survival (OS) rates were 98%, 93% and 100%, respectively (p = 0.001), in the Kaplan-Meier analysis. However, these difference disappeared in a subgroup of stage iA patients in univariate and multivariate analysis. cox regression analysis in stage iA patients also revealed no significant differences in survival outcome across the three groups. In conclusion, EEC-AIA exhibited specific clinicopathological characteristics that were probably associated with favorable survival outcomes. the characteristics and survival outcomes of eec-A were similar to those of eec without adenomyosis in stage iA patients.

show abstract

Tumor Characteristics and Survival Outcome of Endometrial Cancer Arising in Adenomyosis: An Exploratory Analysis

Abstract: The study suggested that endometrial cancer arising in adenomyosis may be an aggressive variant of endometrial cancer.

Cited by 29 publications

References 49 publications

Prognostic significance of co‐existent adenomyosis on outcomes and tumor characteristics of endometrial cancer: A meta‐analysis

Prognostic significance of co‐existent adenomyosis on outcomes and tumor characteristics of endometrial cancer: A meta‐analysis

Association of benign gynaecological diseases and risk of endometrial and ovarian cancers

The clinicopathological characteristics and survival outcomes of endometrial carcinoma coexisting with or arising in adenomyosis: A pilot study

Contact Info

Product

Resources

About