Tumor budding as a risk factor for nodal metastasis in pT1 colorectal cancers: a meta-analysis

Cappellesso, Rocco; Luchini, Claudio; Veronese, Nicola; Mele, Marcello; Rosa-Rizzotto, E.; Guido, Ennio; Lazzari, F. De; Pilati, Pierluigi; Farinati, Fabio; Realdon, Stefano; Solmi, Marco; Fassan, Matteo

doi:10.1016/j.humpath.2017.04.013

Cited by 77 publications

(70 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 However, the high intensity of TB was not always correlated with pathological poor differentiation, 9,10 suggesting that TB cells may have a different prognostic role compared with tumor grade in cancer. Currently, accumulating evidence supports the idea that TB can provide the most useful prognostic information in many solid tumors, including colorectal cancer, 30,31 colon cancer, 32 lung cancer, 33,34 esophageal SCC, 35 pancreatic cancer, 36 breast cancer, 37 cutaneous SCC, 38,39 and OSCC. 12 In our previous studies, we demonstrated that TB was correlated with poor prognosis and LNM, which was independent of TNM classification in oral tongue SCC.…”

Section: Publication Biasmentioning

confidence: 95%

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

et al. 2018

View full text Add to dashboard Cite

Tumor budding (TB) has been suggested as an adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This meta‐analysis evaluated the prognostic role of TB in HNSCC. We systematically reviewed the literatures of electronic databases and performed a meta‐analysis to address the impact of TB on prognosis in HNSCC. Published data were extracted and organized. Then, pooled odds ratios for lymph node metastasis (LNM) and hazard ratios for survival were calculated by using the Mantel‐Haenszel fixed effect model. The results showed that high TB was significantly associated with LNM and worse survival in patients with HNSCC. Moreover, high TB was also correlated with poor prognosis in patients with cT1‐2N0 oral squamous cell carcinoma. TB is a promising prognostic factor associated with LNM and worse survival, which should be included in the routine pathological examination of HNSCC.

show abstract

Section: Publication Biasmentioning

confidence: 95%

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Tumour budding is considered to be a good marker for progression and prognosis and has potential clinical implications in colorectal carcinomas . The International Tumour Budding Consensus Conference (ITBCC) recommended including tumour budding into future colorectal cancer guidelines .…”

Section: Introductionmentioning

confidence: 99%

“…Tumour budding is considered to be a good marker for progression and prognosis and has potential clinical implications in colorectal carcinomas. [1][2][3] The International Tumour Budding Consensus Conference (ITBCC) recommended including tumour budding into future colorectal cancer guidelines. 4 The obstacle of different assessment criteria has been overcome, 4 but the significance of reliability in daily practice has to be clarified further.…”

Section: Introductionmentioning

confidence: 99%

Level of interobserver variability estimation as a valuable tool: assessment of tumour budding in colon cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Richards and colleagues advise segmental resection in cases of incom-plete resection or evidence of lymphovascular invasion (16). The presence of tumor budding may in the future be an additional indicator of potential nodal involvement in these early cancers (17).…”

Section: Discussionmentioning

confidence: 99%

A National Bowel Cancer Screening Programme using FIT: Achievements and Challenges

O’Donoghue¹,

Sheahan²,

MacMathúna³

et al. 2019

Cancer Prevention Research

View full text Add to dashboard Cite

Colorectal cancer accounts for 11% of all cancerrelated deaths in Ireland. With the aim of diagnosing these cancers at an earlier stage, and detecting premalignant lesions, the National Screening Service (NSS) offered a fecal immunochemical test (FIT) to all individuals aged 60 to 69. All individuals in the age range were contacted by post and invited to participate in the programme. Those with a positive FIT result were offered a colonoscopy in an internationally accredited unit. From an eligible population of 488,628, 196,238 individuals participated giving an uptake of 40.2%. Commencing at a FIT threshold of 20 mg Hg/g feces, the positivity rate was 8.6%, which overwhelmed colonoscopy capacity and, thus, the threshold was increased to 45 mg, resulting in an overall 5% positivity rate. A total of 520 individuals had cancer detected (68.3% stage I or II), of which 104 were removed endoscopically (pT1s). Adenomas were present in 54.2% of all colonoscopies, 17.4% deemed high risk. Despite a lower uptake, males were twice as likely to have colorectal cancers as females and had a 59% increased rate of high-risk adenomas diagnosed. Challenges facing the programme include increasing participation, especially among males, and increasing colonoscopy capacity. The ability to alter the sensitivity of FIT to match colonoscopy capacity is a valuable option for such a programme as it ensures that the maximum public health benefit can be achieved within available resources.

show abstract

Tumor budding as a risk factor for nodal metastasis in pT1 colorectal cancers: a meta-analysis

Cited by 77 publications

References 54 publications

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

Level of interobserver variability estimation as a valuable tool: assessment of tumour budding in colon cancer

A National Bowel Cancer Screening Programme using FIT: Achievements and Challenges

Contact Info

Product

Resources

About