Tumor-binding prodrug micelles of polymer–drug conjugates for anticancer therapy in HeLa cells

Jung, Bokyung; Jeong, Yong‐Cheol; Min, Junhong; Kim, Jung-Eun; Song, Yoon‐Jae; Park, Jung-Ki; Park, Jung Hwan; Kim, Jong-Duk

doi:10.1039/c2jm30534h

Cited by 24 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It could also be expected that GA-HRA would be more effective during circulation in vivo due to the targeting ability of HA. 35 Moreover, HRA conjugate showed no cytotoxicity at investigated concentrations ranging from 0.01 µg/mL to 100 µg/mL equivalent to the amount of the conjugate in GA-HRA. Considering the above results (hemolysis, intravenous irritation, and cytotoxicity studies), it might be concluded that HRA conjugate can be used as a safe intravenous injectable nanocarrier for antitumor drugs.…”

mentioning

confidence: 99%

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Yao¹,

Li²,

Sun³

et al. 2014

IJN

View full text Add to dashboard Cite

In order to enhance the in vivo codelivery efficiency of gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanoparticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) conjugate. In this way, GA and ATRA were loaded simultaneously in a nanocarrier and codelivered into the tumor cell through HA receptor-mediated endocytosis. GA-loaded HRA nanoparticles (GA-HRA) were prepared by a dialysis method, and their physicochemical characteristics were investigated as well. GA-HRA exhibited a high drug loading capacity (31.1%), had a particle size in the range of 100–150 nm, and good biocompatibility. HRA nanoparticles were effectively internalized by MCF-7 cells and translocated into the nucleus in a time-dependent manner. The in vivo imaging analysis demonstrated that the fluorescent signals in the tumor were markedly increased with DiR-loaded nanoparticles after intravenous administration compared to free DiR solution, suggesting it has excellent tumor targeting properties. More importantly, GA-HRA exhibited excellent in vivo efficacy with dramatically reduced toxicity. In conclusion, with the assistance of HRA nanoparticles, GA and ATRA can successfully realize an effective combination chemotherapy as well as tumor-targeted delivery.

show abstract

mentioning

confidence: 99%

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Yao¹,

Li²,

Sun³

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…To address these problems, we previously reported fully water‐soluble form of PHS conjugates, composed of partially biodegradable poly(amino acid) and PHS17 that can exert anticancer therapeutic effect to cancer cells. In another study, we also showed that PHS prodrug micelles can significantly enhance the intracellular uptake by using folate ligand attached to the hydrophilic host polymer and acid‐labile linkage between PHS and host polymer 18…”

Section: Introductionmentioning

confidence: 90%

Synthesis of self‐assembled sphingolipid conjugates and their morphology effect on anticancer therapeutic potency

Jung

Jeong

Kim

2012

J. Polym. Sci. A Polym. Chem.

Self Cite

View full text Add to dashboard Cite

The shape of self‐assembling polymer–drug conjugates, influencing the cellular uptake, is one of the important factors to be considered for effective drug delivery. In this study, we described synthesis of polymeric drug conjugates of different morphologies with phytosphingosine (PHS) as a hydrophobic model drug and poly(amino acid) as a hydrophilic host polymer. By varying the amount of PHS grafted to poly(amino acid), PHS–poly(amino acid) conjugates exhibited morphological transition from spherical to worm‐like micellar aggregates in the aqueous media. We investigated the physicochemical properties of self‐assembled structures in terms of hydrodynamic size, surface charge, and critical aggregation concentration. The anticancer therapeutic potency of these self‐assembled structures was also discussed in terms of cellular uptake and cytotoxicity of prodrug micelles as a function of dose and time by in vitro cell study. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

show abstract

“…Jung et al reported the synthesis of phytosphingosine (PHS)-based PDC that could encapsulate DOX and exhibit a synergistic effect against the HeLa cervical cancer cell line. 101 In this report, PHS was conjugate to a modified poly(2-hydroxyethyl- l -aspartamide) (PHEA) polymer and, using a nanoprecipitation method (see Section 3.1.1), assembled in the presence of DOX to form DOX-loaded micelles. The PHS content was deliberately maintained below 10% ( w/w ) as a morphological transition from spherical to worm-like structures was seen.…”

Section: Macromolecular Sapdsmentioning

confidence: 99%

Self-assembling prodrugs

et al. 2017

View full text Add to dashboard Cite

Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. This prodrug strategy relies on modified drugs that possess advantageous pharmacokinetic properties and administration routes over their parent drug. Self-assembling prodrugs represent an emerging class of therapeutic agents capable of spontaneously associating into well-defined supramolecular nanostructures in aqueous solutions. The self-assembly of prodrugs expands the functional space of conventional prodrug design, providing a possible pathway to more effective therapies as the assembled nanostructure possesses distinct physicochemical properties that can be tailored to specific administration routes and disease treatment. In this review, we will discuss the various types of self-assembling prodrugs in development, providing an overview of the methods used to control their structure and function and, ultimately, our perspective on their current and future potential.

show abstract

Tumor-binding prodrug micelles of polymer–drug conjugates for anticancer therapy in HeLa cells

Cited by 24 publications

References 32 publications

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Synthesis of self‐assembled sphingolipid conjugates and their morphology effect on anticancer therapeutic potency

Self-assembling prodrugs

Contact Info

Product

Resources

About