Tumor-associated trypsin inhibitor (TATI) is a good marker of glomerular filtration rate

Tramonti, Gianfranco; Ferdeghini, M; Donadio, Carlo; Annichiarico, C.; Norpoth, M.; Bianchi, R.; Bianchi, Claudio

doi:10.1097/00006231-199805000-00045

Cited by 4 publications

(8 citation statements)

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“…It is of a particular note that is worth mentioning that the blood levels of TATI increase much higher in renal failure but the data points are not scattered. For these reasons TATI can be considered the best marker of renal function among those that were evaluated in this investigation (14,27,28).…”

Section: Discussionmentioning

confidence: 99%

“…After reabsorption they are then further processed in the proximal tubular cells (4,5). Thus a rise in the blood levels of low MW proteins with the decline in renal function occurs (6)(7)(8)(9)(10)(11)(12)(13)(14). Previously, elevation in the blood levels of low MW proteins that have been regarded as tumor markers have been found in compromised renal function (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Renal Function and Blood Level of Chromogranin A

Tramonti¹,

Ferdeghini²,

Annichiarico³

et al. 2001

Renal Failure

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Chromogranin A (CGA) is a low MW (49,000) acidic hydrophilic protein. It is synthesized in the chromaffm granules of the neuroendocrine cells, and has been found circulating in the blood of healthy subjects. The aim of this study was to assess the relationship between serum levels of CGA and renal function. One hundred two renal patients (45 M and 57 F; age 14-76 years, mean 52) participated in the study. Glomerular filtration rate (GFR) was measured by the bladder cumulative method, using 99mTc-DTPA as a tracer. Blood CGA was determined by RIA. Plasma creatinine, beta2microglobulin (beta2m) and tumor associated trypsin inhibitor (TATI) were also determined. The reduction in renal function was associated with an increase in all of the above studied parameters. In patients with advanced renal failure (GFR <20 mL/min) CGA levels increased by 22-fold as compared to the patients with normal renal function (GFR> 100 mL/min). The other studied parameters were also increased but to a lesser degree, e.g., TATI 14-, beta2m 8- and creatinine 5-fold. The results of this study demonstrate that renal handling of the CGA is similar to other low MW proteins, and it accumulates in the blood in renal failure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship Between Renal Function and Blood Level of Chromogranin A

Tramonti¹,

Ferdeghini²,

Annichiarico³

et al. 2001

Renal Failure

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“…Tumor-associated trypsin inhibitor (TATI) is a 6.2 kDa protein and is a tumor marker for ovarian, pancreatic, and gastrointestinal cancer (63). It is exclusively eliminated by the kidneys (64,65) and closely associated with renal function (62,(64)(65)(66)(67). In 99m Tc-DTPA clearance studies, TATI levels rise early with very mild reductions in GFR suggesting it may be a more sensitive marker of renal impairment than creatinine.…”

Section: Tumor Markers-chromogranin a And Tumor-associated Trypsin Inmentioning

confidence: 99%

Measuring Residual Renal Function in Hemodialysis Patients without Urine Collection

Wong

Kamal

Farrington

2016

Seminars in Dialysis

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Many patients on hemodialysis retain significant residual renal function (RRF) but currently measurement of RRF in routine clinical practice can only be achieved using inter-dialytic urine collections to measure urea and creatinine clearances. Urine collections are difficult and inconvenient for patients and staff, and therefore RRF is not universally measured. Methods to assess RRF without reliance on urine collections are needed since RRF provides useful clinical and prognostic information and also permits the application of incremental hemodialysis techniques. Significant efforts have been made to explore the use of serum based biomarkers such as cystatin C, β-trace protein and β -microglobulin to estimate RRF. This article reviews blood-based biomarkers and novel methods using exogenous filtration markers which show potential in estimating RRF in hemodialysis patients without the need for urine collection.

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“…Thus, serum TATI is strongly elevated in patients with severely impaired renal function (Tramonti et al, 1998). Elevated serum and urine levels occur in connection with many types of cancers, especially mucinous ovarian cancer (Halila et al, 1988).…”

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confidence: 99%

“…Elevated levels may also occur in non-malignant diseases, e.g., in pancreatitis (Haglund et al, 1986), severe infections Haglund et al, 1986) and tissue destruction (Matsuda et al, 1985). Hence TATI may function as an acute-phase protein (Ogawa, 1988), also as a marker of pancreatic disease (Haglund et al, 1986), renal dysfunction (Tramonti et al, 1998) and malignancy Huhtala et al, 1982).…”

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confidence: 99%