Tumor‐associated macrophages (TAMs) as biomarkers for gastric cancer: A review

Räihä, Meri R.; Puolakkainen, Pauli

doi:10.1016/j.cdtm.2018.07.001

Cited by 66 publications

(63 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to some reports, they can be positive and, according to others, negative prognostic factors. Prominent macrophage infiltrates are considered to be an adverse prognostic factor in gastric or breast cancer [22,23], whereas controversial results were shown for bladder, lung and thyroid cancer [24][25][26].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Several studies have evaluated the prognostic or predictive significance of TAMs in different neoplasms with ambiguous results. Intense infiltrates of TAMs were linked to unfavourable prognosis in gastric or breast cancer [22,23], whereas controversial results were shown for bladder, lung, and thyroid cancer [24][25][26]. Results obtained for oropharyngeal cancer are also contradictory especially in the context of HR-HPV status and macrophage phenotype.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

et al. 2020

View full text Add to dashboard Cite

Introduction: Human papillomavirus with a high oncogenic potential (HR-HPV) is responsible for more than a half of squamous cell carcinomas of the oropharynx. The HR-HPVdependent cases of this tumour have a better prognosis compared to the HR-HPV-negative cases, despite the usually more advanced disease at the time of diagnosis. In addition to genetic and epigenetic factors, the causes of this more favourable course of the disease are also seen in the participation of the tumour microenvironment, including the patient's immune system. Macrophages are one of the most important elements of the immunocompetent cells landscape that make up the tumour microenvironment. Traditionally, they are divided into 2 groups: inflammatory macrophages with the M1 phenotype and tumour-associated macrophages known as M2 phenotype macrophages. Objective: The aim of this study was to investigate the impact ated with higher rate of nodal failures and a shorter nodal control in both HR-HPV groups. In the group of HR-HPV-negative patients, heavy infiltration of CD163 + macrophages was associated with significantly shorter: loco-regional control (LRC), metastasis-free survival and overall survival (OS). These parameters and prognosis in patients with scanty CD163 + infiltration were similar to favourable outcomes in HR-HPV-positive patients. The relative risk of local-regional recurrence, distant metastases and disease-related death in HR-HPV-negative patients with intense CD163 + infiltrates was, respectively, 4.7, 5.4 and 5.7 compared to patients with scanty infiltrates. Conclusions: Tumours with a positive HR-HPV status demonstrate intense infiltrations of total pool M1/M2 and M2 macrophages. In the group of HPV-negative patients, intensive M1/M2 macrophage infiltrates correlate with higher risk of nodal failures, and intensive M2 infiltrates are an adverse prognostic factor for LRC, metastasis-free survival and OS.

show abstract

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

et al. 2020

View full text Add to dashboard Cite

show abstract

“…They modulate tumorigenesis and adjust the response to therapy. Several studies have reported that TAMs are related to poor prognosis in different tumors as hepatocellular carcinoma, gastric cancer, and lung cancer [15]. Several markers are used to label macrophages.…”

Section: Discussionmentioning

confidence: 99%

Pathologic assessment of tumor-associated macrophages and their histologic localization in invasive breast carcinoma

Mwafy

El-Guindy

2020

J Egypt Natl Canc Inst

View full text Add to dashboard Cite

Background: Tumor-associated macrophages (TAMs) are important in regulating cross-talk between tumor cells and tumor microenvironment. TAMs are involved in multiple steps of tumor progression and invasion. This study aimed to compare CD163 expression with the widely used CD68 pan-macrophage marker in invasive breast carcinoma. Furthermore, it focused on assessing the significance of TAMs localization in relation to clinicopathological parameters. Results: CD68 and CD163 immunohistochemical expressions within TAMs infiltrating both tumor nest (TN) and tumor stroma (TS) were evaluated in 60 specimens with invasive breast carcinoma. High CD68-positive stromal TAMs was significantly related to larger tumor, nodal metastasis and vascular invasion (p = 0.003, 0.037, 0.032, respectively), whereas high CD163-positive stromal TAMs was significantly related to larger tumors, nodal metastasis, stage III tumors, vascular invasion, estrogen receptor (ER) negativity, and triple-negative subtype (p = 0.023, < 0.001, 0.001, 0.022, 0.002, 0.017, respectively). On multivariate analysis, high CD68-positive TAMs infiltrating TS was significantly associated with larger tumor and positive nodal metastasis (p = 0.006 and 0.016, respectively), whereas high CD163 TAMs density within TS was significantly associated with positive vascular invasion, nodal metastasis, and molecular subtypes (p = 0.003, 0.001, and 0.009, respectively). Conclusion: TAMs within tumor stroma and tumor nest have different levels of association with poor prognostic parameters. So, it is of great importance to consider the histologic localization of TAMs in addition to the degree of TAMs infiltration.

show abstract

“…Wnt5a might also be secreted by tumor-associated macrophages (TAMs), which are observed in GC and correlate with poor prognosis (Räihä and Puolakkainen, 2018). Macrophages secrete Wnt5a in response to LPS treatment and H. pylori infection (Zhao et al, 2013).…”

Section: Wnt5a Expression In Gastric Cancermentioning

confidence: 99%

Wnt5a Signaling in Gastric Cancer

Astudillo

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Gastric cancer remains an important health challenge, accounting for a significant number of cancer-related deaths worldwide. Therefore, a deeper understanding of the molecular mechanisms involved in gastric cancer establishment and progression is highly desirable. The Wnt pathway plays a fundamental role in development, homeostasis, and disease, and abnormal Wnt signaling is commonly observed in several cancer types. Wnt5a, a ligand that activates the non-canonical branch of the Wnt pathway, can play a role as a tumor suppressor or by promoting cancer cell invasion and migration, although the molecular mechanisms explaining these roles have not been fully elucidated. Wnt5a is increased in gastric cancer samples; however, most gastric cancer cell lines seem to exhibit little expression of this ligand, thus raising the question about the source of this ligand in vivo. This review summarizes available research about Wnt5a expression and signaling in gastric cancer. In gastric cancer, Wnt5a promotes invasion and migration by modulating integrin adhesion turnover. Disheveled, a scaffolding protein with crucial roles in Wnt signaling, mediates the adhesion-related effects of Wnt5a in gastric cancer cells, and several studies provide growing support for a model whereby Disheveled-interacting proteins mediates Wnt5a signaling to modulate cytoskeleton dynamics. However, Wnt5a might induce other effects in gastric cancer cells, such as cell survival and induction of gene expression. On the other hand, the available evidence suggests that Wnt5a might be expressed by cells residing in the tumor microenvironment, where feedback mechanisms sustaining Wnt5a secretion and signaling might be established. This review analyzes the possible functions of Wnt5a in this pathological context and discusses potential links to mechanosensing and YAP/TAZ signaling.

show abstract

Tumor‐associated macrophages (TAMs) as biomarkers for gastric cancer: A review

Cited by 66 publications

References 48 publications

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

Infiltrates of M2-Like Tumour-Associated Macrophages Are Adverse Prognostic Factor in Patients with Human Papillomavirus-Negative but Not in Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma

Pathologic assessment of tumor-associated macrophages and their histologic localization in invasive breast carcinoma

Wnt5a Signaling in Gastric Cancer

Contact Info

Product

Resources

About