Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery

Jiang, Jipeng; Mei, Jie; Yi, Shaoqiong; Feng, Changjiang; Ma, Yongfu; Liu, Yang; Liu, Ying; Chen, Chunying

doi:10.1016/j.addr.2021.114046

Cited by 36 publications

(21 citation statements)

References 199 publications

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“…To further investigate the role of immune cell infiltration in HCC, TIMER database analysis revealed that the NCBP2 expression was most positively correlated with macrophages (r = 0.551, p = 1.97 × 10 −28 ) and CD4 + T cells (r = 0.484, p = 1.37 × 10 −21 ). Studies have demonstrated that by infiltrating tumor-associated macrophages (TAMs) at a high level in HCC, target TAM infiltration results in tumor growth inhibition in a mouse HCC model [ 42 , 43 ]. Higher infiltrating fractions of activated memory CD4 + T cells were also found in high-risk groups of HCC patients [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma

Zhao

Huang

2022

Diagnostics

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Tumor mutation burdens (TMBs) act as an indicator of immunotherapeutic responsiveness in various tumors. However, the relationship between TMBs and immune cell infiltrates in hepatocellular carcinoma (HCC) is still obscure. The present study aimed to explore the potential diagnostic markers of TMBs for HCC and analyze the role of immune cell infiltration in this pathology. We used OA datasets from The Cancer Genome Atlas database. First, the “maftools” package was used to screen the highest mutation frequency in all samples. R software was used to identify differentially expressed genes (DEGs) according to mutation frequency and perform functional correlation analysis. Then, the gene ontology (GO) enrichment analysis was performed with “clusterProfiler”, “enrichplot”, and “ggplot2” packages. Finally, the correlations between diagnostic markers and infiltrating immune cells were analyzed, and CIBERSORT was used to evaluate the infiltration of immune cells in HCC tissues. As a result, we identified a total of 359 DEGs in this study. These DEGs may affect HCC prognosis by regulating fatty acid metabolism, hypoxia, and the P53 pathway. The top 15 genes were selected as the hub genes through PPI network analysis. SRSF1, SNRPA1, and SRSF3 showed strong similarities in biological effects, NCBP2 was demonstrated as a diagnostic marker of HCC, and high NCBP2 expression was significantly correlated with poor over survival (OS) in HCC. In addition, NCBP2 expression was correlated with the infiltration of B cells (r = 0.364, p = 3.30 × 10−12), CD8+ T cells (r = 0.295, p = 2.71 × 10−8), CD4+ T cells, (r = 0.484, p = 1.37 × 10−21), macrophages (r = 0.551, p = 1.97 × 10−28), neutrophils (r = 0.457, p = 3.26 × 10−19), and dendritic cells (r = 0.453, p = 1.97 × 10−18). Immune cell infiltration analysis revealed that the degree of central memory T-cell (Tcm) infiltration may be correlated with the HCC process. In conclusion, NCBP2 can be used as diagnostic markers of HCC, and immune cell infiltration plays an important role in the occurrence and progression of HCC.

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Section: Discussionmentioning

confidence: 99%

Integrated Analysis of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma

Zhao

Huang

2022

Diagnostics

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“…Strategies, such as directly targeting TME vasculature (angiogenesis), targeting CAFs, and persistent cytokines, such as GM-CSF, IDO1, BAFF and other interleukins, with cancer vaccines have shown relatively consistent antitumoral effectiveness in preclinical models [ 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 ]. DNA vaccines utilizing novel nanobiomaterials include minimally invasive, injectable smart hydrogels [ 230 ]. These are scaffold-based cancer vaccines that allow for spatial and temporal control of antigen and other therapeutic agents and have shown strong antitumor effects via increased DC infiltration [ 231 ].…”

Section: Basic Research In Cancer Immunologymentioning

confidence: 99%

Recent Advances and Challenges in Cancer Immunotherapy

Peterson

Denlinger

Yang

2022

Cancers

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Cancer immunotherapy has revolutionized the field of oncology in recent years. Harnessing the immune system to treat cancer has led to a large growth in the number of novel immunotherapeutic strategies, including immune checkpoint inhibition, chimeric antigen receptor T-cell therapy and cancer vaccination. In this review, we will discuss the current landscape of immuno-oncology research, with a focus on elements that influence immunotherapeutic outcomes. We will also highlight recent advances in basic aspects of tumor immunology, in particular, the role of the immunosuppressive cells within the tumor microenvironment in regulating antitumor immunity. Lastly, we will discuss how the understanding of basic tumor immunology can lead to the development of new immunotherapeutic strategies.

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“…As previously discussed, via crosstalk between tumor cells, immune cells, and microbes within the TME, tumors can facilitate their own growth and escape immune recognition. There are many types of vaccines currently under investigation, including molecular-based, cell-based, and vector-based vaccines, which all target those specific interactions between elements of the TME [ 137 ]. The vaccines activate immune cells, such as TAMs, after they are exposed to specific tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs), causing them to attack malignant cells [ 129 ].…”

Section: Diagnosis and Treatment Implicationsmentioning

confidence: 99%

The Role of the Microbiome on the Pathogenesis and Treatment of Colorectal Cancer

Tokumaru

et al. 2022

Cancers

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The gut microbiome has long been known to play a role in various aspects of health modulation, including the pathogenesis of colorectal cancer (CRC). With immunotherapy recently emerging as a successful treatment in microsatellite instability high (MSI-high) CRC, and with a newly demonstrated involvement of the gut microbiome in the modulation of therapeutic responses, there has been an explosion of research into the mechanisms of microbial effects on CRC. Harnessing and reprogramming the microbiome may allow for the expansion of these successes to broader categories of CRC, the prevention of CRC in high-risk patients, and the enhancement of standard treatments. In this review, we pull together both well-documented phenomena and recent discoveries that pertain to the microbiome and CRC. We explore the microbial mechanisms associated with CRC pathogenesis and progression, recent advancements in CRC systemic therapy, potential options for diagnosis and prevention, as well as directions for future research.

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Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery

Cited by 36 publications

References 199 publications

Integrated Analysis of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma

Integrated Analysis of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma

Recent Advances and Challenges in Cancer Immunotherapy

The Role of the Microbiome on the Pathogenesis and Treatment of Colorectal Cancer

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