Tumeur urothéliale de vessie T1 : valeur pronostique du franchissement de la muscularis mucosae (T1a/T1b). Étude multicentrique du Comité de cancérologie de l’Association française d’urologie (CCAFU)

The Prognostic Value of T1 Bladder Cancer Substaging: A Single Institution Retrospective Study

“…We found that the extent of lamina propria invasion is a relevant prognostic factor for tumour progression, disease-specific survival and overall survival in uni- and multivariable analyses. This observation is in concordance with previous reports [5,6,7,8,9,16,17,18,19,20,21,22]. The depth of lamina propria invasion has been significant in multivariable analyses for overall survival in three studies using the substaging system based on MM identification [9,16,21].…”

“…The prognostic value of T1 substaging has previously been reported [5,6,7,8,9,16,17,18,19,20,21,22]. We found that the extent of lamina propria invasion is a relevant prognostic factor for tumour progression, disease-specific survival and overall survival in uni- and multivariable analyses.…”

“…Substaging rates range from 58 to 100% in various publications [6,9,16,17,20,21,23], which argues against the usefulness of the MM as a tool for T1 substaging [23]. We were able to subclassify T1 tumours in 88% of the patients.…”

“…Depth of invasion within the subepithelial connective tissue in the TUR specimen has a prognostic value with respect to the risk of tumour progression [6,7,8,16,17,18,19,20,21,22]. A distinctive prognosis can be expected for tumours with different levels of invasion [4].…”

“…A second proposal divides T1 patients into two populations only. Tumours superficial to the MM or reaching the MM but not passing through it were classified as pT1a, and tumours passing through the MM and invading the submucosa were considered to be pT1b [16,21,24]. A third proposal subclassifies T1 tumours as either with MM invasion (pT1b) or without (pT1a) [6,7,17,20,25,26].…”