Development of effective immune therapies for cancer patients requires better understanding of hurdles that prevent the generation of effective anti-tumor immune responses. Administration of α-galactosylceramide (α-GalCer) in animals enhances anti-tumor immunity via activation of the invariant natural killer T (iNKT) cells. However, repeated injections of α-GalCer result in long-term unresponsiveness or anergy of iNKT cells, severely limiting its efficacy in tumor eradication. The mechanisms leading to iNKT c…
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