Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening

Zafari, Parisa; Golpour, Monireh; Hafezi, Nasim; Bashash, Davood; Esmaeili, Seyed‐Alireza; Tavakolinia, Naeimeh; Rafiei, Alireza

doi:10.1002/iub.2413

Cited by 10 publications

(8 citation statements)

References 126 publications

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“…PTB is a widespread disease that seriously threatens the lives and health of residents in Xinjiang and restricts social and economic development. It is considered a social and public health problem [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis

et al. 2021

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Aim This study mainly evaluates the clinical characteristics and chest chest computed tomography (CT) findings of AFB-positive and AFB-negative pulmonary tuberculosis (PTB) patients to explore the relationship between AFB-positive and clinico-radiological findings. Methods A retrospective analysis of 224 hospitalized tuberculosis patients from 2018 to 2020 was undertaken. According to the AFB smear results, they were divided into AFB-positive pulmonary tuberculosis (positive by Ziehl–Neelsen staining) and AFB-negative pulmonary tuberculosis and patients’ CT results and laboratory test results were analyzed. Results A total of 224 PTB patients were enrolled. AFB-positive (n = 94, 42%) and AFB-negative (n = 130, 58%). AFB-positive patients had more consolidation (77.7% vs. 53.8%, p < 0.01), cavity (55.3% vs. 34.6%, p < 0.01), calcification (38.3% vs. 20%, p < 0.01), bronchiectasis (7.5% vs. 1.5%, p < 0.05), bronchiarctia (6.4% vs. 0.8%, p < 0.05), and right upper lobe involvement (57.5% vs. 33.1%, p < 0.01), left upper lobe involvement (46.8% vs. 33.1%, p < 0.05) and lymphadenopathy (58.5% vs. 37.7%, p < 0.01). Conclusion The study found that when pulmonary tuberculosis patients have consolidation, cavity, upper lobe involvement and lymphadenopathy on chest CT images, they may have a higher risk of AFB-positive tuberculosis.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis

et al. 2021

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“…Numerous publications have already reported on the correlation between TB and various diseases, such as rheumatoid arthritis (RA) [ 24 ], chronic obstructive pulmonary disease (COPD) [ 25 ], corona virus disease 2019 (COVID-19) [ 26 ], and lung adenocarcinomas (LA) [ 27 ]. To delve further into the potential involvement of Ub-related genes in these diseases, we conducted an analysis using ssGSEA.…”

Section: Resultsmentioning

confidence: 99%

Identification and validation of ubiquitination-related signature and subgroups in immune microenvironment of tuberculosis

Zhou,

Shen,

et al. 2023

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Background: Mycobacterium tuberculosis (Mtb) is the bacterial pathogen responsible for causing tuberculosis (TB), a severe public health concern that results in numerous deaths worldwide. Ubiquitination (Ub) is an essential physiological process that aids in maintaining homeostasis and contributes to the development of TB. Therefore, the main objective of our study was to investigate the potential role of Ub-related genes in TB. Methods: Our research entailed utilizing single sample gene set enrichment analysis (ssGSEA) in combination with several machine learning techniques to discern the Ub-related signature of TB and identify potential diagnostic markers that distinguish TB from healthy controls (HC). Results: In summary, we used the ssGSEA algorithm to determine the score of Ub families (E1, E2, E3, DUB, UBD, and ULD). Notably, the score of E1, E3, and UBD were lower in TB patients than in HC individuals, and we identified 96 Ub-related differentially expressed genes (UbDEGs). Employing machine learning algorithms, we identified 11 Ub-related hub genes and defined two distinct Ub-related subclusters. Notably, through GSVA and functional analysis, it was determined that these subclusters were implicated in numerous immune-related processes. We further investigated these Ub-related hub genes in four TB-related diseases and found that TRIM68 exhibited higher correlations with various immune cells in different conditions, indicating that it may play a crucial role in the immune process of these diseases. Conclusion: The observed enrichment of Ub-related gene expression in TB patients emphasizes the potential involvement of ubiquitination in the progression of TB. These significant findings establish a basis for future investigations to elucidate the molecular mechanisms associated with TB, select suitable diagnostic biomarkers, and design innovative therapeutic interventions for combating this fatal infectious disease.

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“…En ese sentido, es claro que la detección de tuberculosis latente antes de iniciar la terapia biológica puede minimizar complicaciones posteriores. En línea con lo anterior, en varios estudios se han evaluado biomarcadores adicionales y otros procedimientos para la detección temprana de la infección 24 .…”

Section: Discussionunclassified

Frecuencia de positividad de la prueba de intradermorreacción a tuberculina en una cohorte de pacientes con artritis reumatoide

et al. 2021

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Introducción. La artritis reumatoide es una enfermedad autoinmunitaria, crónica y deformante asociada con discapacidad. Quienes la padecen reciben inmunosupresores y tienen un gran riesgo de desarrollar tuberculosis. La prueba de intradermorreacción a la tuberculina se utiliza como tamización en quienes van a recibir terapia biológica.Objetivo. Evaluar la frecuencia de positividad en la prueba de intradermorreacción a la tuberculina en una cohorte de pacientes con artritis reumatoide.Materiales y métodos. Se hizo un estudio descriptivo de corte transversal de una cohorte de pacientes con artritis reumatoide a quienes se les practicó la prueba de tuberculina antes de iniciar la terapia biológica o en el momento del cambio de tratamiento. Los pacientes presentaban enfermedad moderada o grave y eran candidatos para iniciar o cambiar de terapia biológica. Se definió el valor de ≥6 mm como punto de corte para la positividad de la prueba y se hizo un análisis descriptivo de cada una de las variables. Resultados. Se incluyeron 261 pacientes con artritis reumatoide, 92 % de ellos eran mujeres, la edad promedio fue de 55 años (desviación estándar, DE=13,92) y el tiempo desde el diagnóstico era de 12,3 años (DE=8,54). La frecuencia de positividad de la prueba fue de 15,71 % (n=41). Nueve de los 41 pacientes positivos habían recibido la prueba previamente (entre 1 y 6 años antes), todos con resultado negativo; 18 (43,9 %) de ellos venían recibiendo tratamiento con glucocorticoides y todos los 41 (100 %) recibían metotrexate.Conclusiones. La frecuencia de positividad de la prueba de tuberculina en pacientes colombianos con artritis reumatoide fue de aproximadamente 16 %. Se recomienda optimizar las estrategias para detectar esta condición y darle un tratamiento oportuno y, así, disminuir el riesgo de reactivación de la tuberculosis.

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Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening

Cited by 10 publications

References 126 publications

Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis

Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis

Identification and validation of ubiquitination-related signature and subgroups in immune microenvironment of tuberculosis

Frecuencia de positividad de la prueba de intradermorreacción a tuberculina en una cohorte de pacientes con artritis reumatoide

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