Tubal Sterilization and Use of an IUD and Risk of Cervical Cancer

Li, Huiqing; Thomas, David B.; Jin, Panpan; Wu, Fan

doi:10.1089/152460900318498

Cited by 18 publications

(12 citation statements)

References 48 publications

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“…As expected, cervical smear screening was shown in this study to reduce the risk of both HPV-16 and HPV-18 tumor types. The reduced risk in women who had used an IUD likely represents an effect of screening at the time of IUD insertion or removal, a phenomenon also reported from China (44).…”

Section: Discussionmentioning

confidence: 80%

Human Papillomaviruses and Cervical Cancer in Bangkok. I. Risk Factors for Invasive Cervical Carcinomas with Human Papillomavirus Types 16 and 18 DNA

Thomas

Ray²,

Koetsawang³

et al. 2001

American Journal of Epidemiology

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Personal interviews, tests for antibodies to herpes simplex virus type 2, Treponema pallidum, and hepatitis B, tests for hepatitis B surface antigen (HBsAg), and polymerase chain reaction-based assays for human papillomavirus (HPV) DNA in cervical scrapings were obtained from 190 women with squamous cell and 42 women with adenomatous cervical carcinoma and from 291 hospitalized controls diagnosed in Bangkok, Thailand, between September 1991 and September 1993. Risk was strongly associated with oncogenic HPV types, with types 16 and 18 predominating in squamous and adenomatous lesions, respectively. The 126 cases with HPV-16 and the 42 cases with HPV-18 were compared with 250 controls with no evidence of any HPV. The risk of both viral tumor types increased with decreasing age at first intercourse in this predominantly monogamous population, which may be explained by more visits to prostitutes by the husbands of cases with early than late age at first intercourse. HPV-16 tumors were weakly associated with HBsAg carrier state and smoking. The risk of tumors of both viral types increased with parity and use of oral contraceptives but not with injectable progestogens. Factors that may predispose to persistent, oncogenic HPV-16 or -18 infection may include estrogens or progestins in the presence of estrogens, immunosuppression, and smoking, but other factors related to low socioeconomic status are also involved.

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Section: Discussionmentioning

confidence: 80%

Human Papillomaviruses and Cervical Cancer in Bangkok. I. Risk Factors for Invasive Cervical Carcinomas with Human Papillomavirus Types 16 and 18 DNA

Thomas

Ray²,

Koetsawang³

et al. 2001

American Journal of Epidemiology

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“…Previous studies have shown a decreased risk for cervical cancer among intrauterine device users [Li et al, 2000;Hammouda et al, 2005;Castellsague et al, 2006]. Castellsague et al [2006] found a lower risk for cervical adenocarcinomas even after adjustment for HPV status and screening history, and Hammouda et al [2005] and Li et al [2000] observed that the protective effect of intrauterine devices was even greater in long-term users. A single study showed that intrauterine device users had an increased clearance rate of HPV 18 [Munoz et al, 2009].…”

Section: Discussionmentioning

confidence: 88%

Persistence of high‐risk human papillomavirus infection in a population‐based cohort of Danish women

Nielsen¹,

Kjær²,

Munk³

et al. 2010

Journal of Medical Virology

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Persisting human papillomavirus (HPV) infection is a critical step in cervical carcinogenesis. This study was conducted to determine the type-specific HPV persistence and risk factors for persistence of high-risk HPV infections in a large cohort of Danish women. The study was based on a population-based prospective cohort study of women aged 20-29 years. Participants were interviewed and underwent two gynecological examinations 2 years apart. Women with Hybrid Capture 2 results at enrolment and a follow-up visit were included in the analysis (n = 7,418). Persistence was defined as positivity for the same high-risk HPV type at both examinations. Overall, 4.2% of the women had persistent HPV infection, accounting for 26.9% of the initially HPV-positive women. HPV 16, HPV 58, and HPV 31, all from species group alpha 9, were the most persistent types; however, other high-risk HPV types that are detected rarely in cancer cases were also likely to persist. The number of high-risk HPV types and detection of HPV 16 infection at baseline and ever use of oral contraceptives increased the risk for persistence. The risk factor analyses also showed that use of an intrauterine device decreased the risk for persistent high-risk HPV infection among women with one high-risk HPV type at baseline. No association was found with viral load or smoking. In conclusion, persistent high-risk HPV infection, especially HPV 16 persistence, was common among women positive for high-risk HPV.

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“…In a Chinese study 15 , IUCD use was associated with a decreased risk of cervical carcinoma attributed mainly to the frequent Pap smear examinations in this population. British authors 16 reported a higher prevalence of cervical intraepithelial neoplasia among IUCD users as compared to non-users, and they too demanded further investigation.…”

Section: Discussionmentioning

confidence: 82%

Pre-malignant and malignant cervical pathologies among inert and copper-bearing intrauterine contraceptive device users: A 10-year follow-up study

Ganacharya

Bhattoa

Batar

2006

The European Journal of Contraception & Reproductive Health

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Tubal Sterilization and Use of an IUD and Risk of Cervical Cancer

Cited by 18 publications

References 48 publications

Human Papillomaviruses and Cervical Cancer in Bangkok. I. Risk Factors for Invasive Cervical Carcinomas with Human Papillomavirus Types 16 and 18 DNA

Human Papillomaviruses and Cervical Cancer in Bangkok. I. Risk Factors for Invasive Cervical Carcinomas with Human Papillomavirus Types 16 and 18 DNA

Persistence of high‐risk human papillomavirus infection in a population‐based cohort of Danish women

Pre-malignant and malignant cervical pathologies among inert and copper-bearing intrauterine contraceptive device users: A 10-year follow-up study

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