Tryptophan Depletion Affects Heart Rate Variability and Impulsivity in Remitted Depressed Patients with a History of Suicidal Ideation

Booij, Linda; Swenne, Cees A.; Brosschot, J. F.; Haffmans, P.M.J.; Thayer, Julian F.; Does, Willem Van der

doi:10.1016/j.biopsych.2006.02.010

Cited by 75 publications

(72 citation statements)

References 59 publications

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“…When body mass was controlled for, HRV, as measured by PNN50, was found to be negatively associated with SSRT. This is consistent with previous findings of HRV being inversely associated with impulse control (13,14), and may help to explain the link between HRV and dieting success.…”

Section: Discussionsupporting

confidence: 92%

“…In accordance with findings linking frequency domain HRV measures and dieting success (12,21), It was expected that greater LF/HF and lower HF would be predictive of greater post-intervention weight gain. It was also expected that, in accordance with previous research (13,14), greater time domain HRV would be associated with greater impulse control.…”

Section: Introductionsupporting

confidence: 59%

“…Heart rate variability (HRV), the variation in beat-to-beat intervals in an individual's cardiac rhythm (12), is associated with impulsivity, with greater HRV being predictive of increased inhibitory neural processes and impulse control (13,14). This enables HRV to be used as a physiological marker of inhibitory capacity (15).…”

Section: Introductionmentioning

confidence: 99%

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Cardiac autonomic regulation as a predictor for childhood obesity intervention success

et al. 2017

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Childhood obesity is a major public health concern; behavioural interventions induce weight reduction in some, but success is variable. Heart rate variability (HRV) has been associated with impulse control and extent of dieting success. This study investigated the relationship between HRV and post childhood obesity intervention weight-management success, and involved recording the frequency-domain HRV measures LF/HF and HF, and the time-domain measure PNN50. It was expected that greater LF/HF and lower HF would be associated with greater post-intervention weight gain, and that greater PNN50 would be associated with greater impulse control. Seventy-four participants aged 9-14 (M 10.7, SD 1.1) attended a weight-management camp, where HRV was recorded. Stop signal reaction time (SSRT) was also recorded as a measure of impulse control. As expected, SSRT was positively associated with pre-intervention body mass (r = .301, p = .010) and negatively associated with PNN50 (Beta = .29, p = .031). Post-intervention body mass change was positively associated with LF/HF (Beta = .34, p = .037), but was not associated with HF. Lifestyle interventions may have a greater chance of effectively supporting long-term weight-management for children with lower LF/HF; assessing HRV of obese children may be helpful in informing obesity treatment decisions.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 59%

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Cardiac autonomic regulation as a predictor for childhood obesity intervention success

et al. 2017

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“…[23][24][25][26][27][28] It is possibly the most widely investigated neurotransmitter in mental health research. Postmortem, neuroimaging, genetic and pharmacological challenge studies have shown that alterations in 5-HT function can occur at many different levels, including changes in synthesis, release, receptor function/expression, reuptake and transport.…”

Section: J Psychiatry Neurosci 2015;40(1)mentioning

confidence: 99%

Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology

Booij

Tremblay

Szyf

et al. 2015

jpn

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“…3 Exclusion criteria were substance abuse within the last 3 months, psychosis (lifetime), major physical illness, lactation, and pregnancy. All of the patients took part in one of two consecutive ATD experiments on the effects of high-dose and low-dose ATD on neuropsychological functioning (Booij et al, 2006;Booij, Van der Does, Haffmans, Riedel, et al, 2005). The two ATD experiments differed in the composition of a neuropsychological test battery but were identical on all other aspects, including design, procedure, experimenter, research room, symptom assessments, and duration.…”

Section: Participantsmentioning

confidence: 99%

Cognitive and serotonergic vulnerability to depression: Convergent findings.

Booij¹,

Does²

2007

Journal of Abnormal Psychology

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Cognitive reactivity (CR) is a psychological vulnerability marker of depression, whereas response to acute tryptophan depletion (ATD; a serotonergic challenge procedure) is a biological vulnerability marker. The aim of this study was to investigate the relationship between these markers. Thirty-nine remitted depressed patients participated in 2 ATD sessions in a double-blind crossover design. CR, assessed prior to the ATD sessions, predicted depressive response to high-dose ATD. CR also diminished the effects of 2 known predictors of ATD response: gender and residual symptoms. Neuroticism and behavioral inhibition were unrelated to ATD response. CR is associated with an increased sensitivity to reductions of serotonin concentrations. These findings present a small step toward unifying cognitive and neurobiological theories of depression.

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Tryptophan Depletion Affects Heart Rate Variability and Impulsivity in Remitted Depressed Patients with a History of Suicidal Ideation

Cited by 75 publications

References 59 publications

Cardiac autonomic regulation as a predictor for childhood obesity intervention success

Cardiac autonomic regulation as a predictor for childhood obesity intervention success

Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology

Cognitive and serotonergic vulnerability to depression: Convergent findings.

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