2015
DOI: 10.1007/s00436-015-4488-x
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Abstract: This study used a murine model of Chagas disease to investigate the isolated and combined impact of Trypanosoma cruzi infection and benznidazole (BZ) therapy on liver structure and function. Male C57BL/6 mice were challenged with T. cruzi and BZ for 15 days. Serum levels of cytokines and hepatic enzymes, liver oxidative stress, morphology, collagen, and glycogen content were monitored. Separately, T. cruzi infection and BZ treatment resulted in a pro-oxidant status and hepatic reactive damage. Concurrently, bo… Show more

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Cited by 48 publications
(50 citation statements)
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“…Thus, the findings observed here indicate that curcumin reduced Bz toxicity, an effect potentially mediated by the attenuation of inflammation and liver oxidative damage caused by both infection and chemotherapy. This hypothesis is reinforced by reduced lipid and protein oxidation in liver tissue in curcumin-treated mice, which is consistent with the action of antioxidant drugs used to treat intoxication by inducers of oxidative stress, including Bz (7,10). Thus, our findings indicate that by limiting the toxic effects of Bz, the combination of the drug with curcumin may be a better-tolerated therapeutic strategy than the use of Bz alone.…”
Section: Discussionsupporting
confidence: 85%
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“…Thus, the findings observed here indicate that curcumin reduced Bz toxicity, an effect potentially mediated by the attenuation of inflammation and liver oxidative damage caused by both infection and chemotherapy. This hypothesis is reinforced by reduced lipid and protein oxidation in liver tissue in curcumin-treated mice, which is consistent with the action of antioxidant drugs used to treat intoxication by inducers of oxidative stress, including Bz (7,10). Thus, our findings indicate that by limiting the toxic effects of Bz, the combination of the drug with curcumin may be a better-tolerated therapeutic strategy than the use of Bz alone.…”
Section: Discussionsupporting
confidence: 85%
“…It has been demonstrated that inflammatory cells recruited to infected organs activate molecular mechanisms against T. cruzi (the respiratory burst) (5, 6), which causes cumulative reactive damage, especially in cardiac tissue (7,10). Thus, antioxidant drugs have shown promising results in attenuating cardiac oxidative damage and ChC progression (25,59).…”
Section: Discussionmentioning
confidence: 99%
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“…In addition, increases in biomarkers of hepatotoxicity and liver histopathological alterations have been shown in mice (Strauss et al 2013) and rats (Rendon 2014) after BZL exposure, possibly associated with oxidative injury. Indeed, Dias Novaes et al (2015) recently demonstrated an increased in lipid peroxidation and protein carbonylation in BZL-treated mice, thus confirming an association between oxidative stress and hepatic damage. Presently, there are scarce reports analyzing the oxidative potential of pharmacological relevant BZL concentrations in experimental models of human liver.…”
Section: Introductionmentioning
confidence: 74%