Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes

Giongo, Janice Luehring; Vaucher, Rodrigo de Almeida; Silva, Aleksandro S. Da; Oliveira, Camila Belmonte; Mattos, Cristiane Bastos de; Baldissera, Matheus D.; Sagrillo, Michele Rorato; Monteiro, Sílvia González; Custódio, Dayana Lacerda; Matos, Marcielly Souza de; Sampaio, Paulo de Tarso Barbosa; Teixeira, Hélder Ferreira; Koester, Letícia Scherer; Veiga, Valdir Florêncio da

doi:10.1016/j.micpath.2016.12.006

Cited by 25 publications

(19 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The essential oil of Aniba canelilla (HBK) Mez, popularly known as “bark-precious” (precious bark), presented as a major constituent 1-nitro-2-phenylethane, a rare molecule in plants, and methyleugenol, and the oil presented results against T. evansi . Methyleugenol was slightly more active than 1-nitro-2-phenylethane, and in vitro studies showed that the oil extracted from the stems of A. canelilla can be considered a potential natural treatment for trypanosomiasis [ 63 ].…”

Section: Essential Oils With Trypanocidal Activitymentioning

confidence: 99%

Trypanocidal Essential Oils: A Review

et al. 2020

View full text Add to dashboard Cite

Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.

show abstract

Section: Essential Oils With Trypanocidal Activitymentioning

confidence: 99%

Trypanocidal Essential Oils: A Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is a yellowish-brown oil, denser than water, which have the characteristic aroma of the specie. It can be extracted from the trunk wood, branches, leaves, thin stems, and barks, by steam distillation or hydrodistillation, using a Clevenger-type apparatus, with a yield between 0.2 to 1.3% (Gottlieb and Magalhães, 1960a;Oger et al, 1994;Taveira et al, 2003;Da Silva et al, 2007;Silva et al, 2009;Silva et al, 2014;Barbosa et al, 2017;Giongo et al, 2017). Several factors, such as humidity and incidence of light, physiological, and geographical variations, environmental conditions, and genetic factors, can influence the production of AcOE.…”

Section: Essential Oilmentioning

confidence: 99%

Aniba canelilla (Kunth) Mez (Lauraceae): A Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties

et al. 2020

View full text Add to dashboard Cite

Aniba canelilla (Kunth) Mez, popularly known as "casca preciosa" (precious bark), falsa canela (cinnamon-scented) Casca-do-maranhão (bark of maranhão), and Folha-preciosa (precious leaf), is an aromatic species of the Lauraceae family, widely distributed in the Amazon region. In traditional medicine, it is indicated for the treatment of a great diversity of diseases, including digestive, respiratory, inflam]matory, painful, and central nervous system disorders, it is administered mainly in the form of tea or decoction orally. Its essential oil is referred to as a natural antioxidant for food preservation and disease control, showing great potential for use in the cosmetics, perfumery, and pharmaceutical products sector. The present review aimed to discuss critically and comprehensively the ethnobotanical characteristics, phytochemical constitution, and scientifically tested biological properties of A. canelilla, systematizing the knowledge about the species and proposing new perspectives for research and development. The chemical composition of A. canelilla includes 1-nitro-2-phenylethane, metyleugenol, eugenol, safrol, anabasin, anbin, tannin, a-pinene, b-pinene, b-felandren, b-caryophyllene, b-sesquifelandren, p-cymene, linalool, a-copaene, and spatulenol. Researches with ethanolic extracts, essential oils, and major constituents (1-nitro-2-phenylethane and metyleugenol) have revealed antioxidant, antinociceptive, anti-inflammatory, cardio-modulating, hypotensive (vasorelaxant), hypnotic, anxiolytic, anticholinesterase, and antibiotic properties (trypanomicidal, leishmanicidal, and antifungal). Some of these effects are potentially beneficial for aging-related diseases treatment, such as cardio and cerebrovascular,

show abstract

“…1-Nitro-2-phenylethane (NPH) is a volatile compound found in the EOs of Aniba canelilla and Dennettia tripetala [58], and was the first nitrocomponent isolated from plants [238,239]. Several pharmacological activities for NPH have been reported, including anti-inflammatory [240], antinociceptive [241], trypanocidal [242], cytoprotective [243], anxiolytic and hypnotic effects [58]. NPH also presents vasodilator activity via stimulation of soluble guanylil cyclase [244], and induces vagal-vagal bradycardia in normotensive rats [245].…”

Section: -Nitro-2-phenylethanementioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

View full text Add to dashboard Cite

Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

show abstract

Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes

Cited by 25 publications

References 23 publications

Trypanocidal Essential Oils: A Review

Trypanocidal Essential Oils: A Review

Aniba canelilla (Kunth) Mez (Lauraceae): A Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

Contact Info

Product

Resources

About