DOI: 10.1016/j.clnesp.2016.04.015
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Maja Bučar Pajek, Jernej Pajek

Abstract: The most important mechanism for protein degradation and muscle wasting on cellular level is the ubiquitin-proteasome system (UPS). This system is activated in a uraemic milieu because of its hormonal changes, metabolic acidosis, low-grade inflammation and insulin resistance, which are associated with a worsening renal function from an early stage. Diabetic uraemic patients have a higher prevalence and more advanced forms of uraemic sarcopenia. Physical inactivity promotes degradation of muscle proteins on a c…

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