Abstract:Stimulation of the T-cell receptor (TCR) activatesCa 2؉ entry across the plasma membrane, which is a key triggering event for the T-cell-associated immune response. We show that TRPC3 channels are important for the TCR-dependent Ca 2؉ entry pathway. The TRPC3 gene was found to be damaged in human T-cell mutants defective in Ca 2؉ influx. Mutations of the TRPC3 gene were accompanied by changes of TRPC3 gene expression. Introduction of the complete human TRPC3 cDNA into those mutants rescued Ca 2؉ currents as we… Show more
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