Troxerutin (TXN) potentiated 5-Fluorouracil (5-Fu) treatment of human gastric cancer through suppressing STAT3/NF-κB and Bcl-2 signaling pathways

Evaluation of drug sensitivity, immunological characteristics, and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatics and pan-cancer analysis

“…Studies have shown that TXN has an antitumor function in human gastric cancer cells by inhibiting the p-STAT3/NF-κB and Bcl-2 signalling pathways [31]. This conclusion seems to contradict our result.…”

Evaluation of drug sensitivity, immunological characteristics, and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatics and pan-cancer analysis

“…Studies have shown that TXN has an antitumor function in human gastric cancer cells by inhibiting the p-STAT3/NF-κB and Bcl-2 signalling pathways [31]. This conclusion seems to contradict our result.…”

Evaluation of immunological characteristics and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatic analysis

“…Interestingly, ARNTL also played a protective role and was downregulated in our study. Studies have shown that TXN has an antitumor function in human gastric cancer cells by inhibiting the p-STAT3/NF-κB and Bcl-2 signalling pathways [31]. This conclusion seems to contradict our result.…”

Troxerutin Potentiated Temozolomide Induced Antitumor Effect in 2D and 3D Glioblastoma Models

“…The combined treatment resulted in a nuclear accumulation of p53, a key pro‐apoptotic marker, strengthening the hypothesis that TROX potentiates the pro‐apoptotic effect of TMZ. These findings are consistent with previous evidence showing that TROX enhanced 5‐FU‐induced apoptosis in gastric cancer cells, suggesting its potential as a broad‐spectrum adjuvant to enhance chemotherapy efficacy via apoptotic signalling [ 37 ]. In GBM, cellular metabolism is profoundly altered, with intense metabolic activity and basal oxidative stress levels.…”

Evaluation of drug sensitivity, immunological characteristics, and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatics and pan-cancer analysis

“…Studies have shown that TXN has an antitumor function in human gastric cancer cells by inhibiting the p-STAT3/NF-κB and Bcl-2 signalling pathways [31]. This conclusion seems to contradict our result.…”

Evaluation of immunological characteristics and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatic analysis

“…Interestingly, ARNTL also played a protective role and was downregulated in our study. Studies have shown that TXN has an antitumor function in human gastric cancer cells by inhibiting the p-STAT3/NF-κB and Bcl-2 signalling pathways [31]. This conclusion seems to contradict our result.…”

Troxerutin Potentiated Temozolomide Induced Antitumor Effect in 2D and 3D Glioblastoma Models

“…The combined treatment resulted in a nuclear accumulation of p53, a key pro‐apoptotic marker, strengthening the hypothesis that TROX potentiates the pro‐apoptotic effect of TMZ. These findings are consistent with previous evidence showing that TROX enhanced 5‐FU‐induced apoptosis in gastric cancer cells, suggesting its potential as a broad‐spectrum adjuvant to enhance chemotherapy efficacy via apoptotic signalling [ 37 ]. In GBM, cellular metabolism is profoundly altered, with intense metabolic activity and basal oxidative stress levels.…”

Evaluation of drug sensitivity, immunological characteristics, and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatics and pan-cancer analysis

“…Studies have shown that TXN has an antitumor function in human gastric cancer cells by inhibiting the p-STAT3/NF-κB and Bcl-2 signalling pathways [31]. This conclusion seems to contradict our result.…”

Evaluation of immunological characteristics and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatic analysis

“…Interestingly, ARNTL also played a protective role and was downregulated in our study. Studies have shown that TXN has an antitumor function in human gastric cancer cells by inhibiting the p-STAT3/NF-κB and Bcl-2 signalling pathways [31]. This conclusion seems to contradict our result.…”

Troxerutin Potentiated Temozolomide Induced Antitumor Effect in 2D and 3D Glioblastoma Models

“…The combined treatment resulted in a nuclear accumulation of p53, a key pro‐apoptotic marker, strengthening the hypothesis that TROX potentiates the pro‐apoptotic effect of TMZ. These findings are consistent with previous evidence showing that TROX enhanced 5‐FU‐induced apoptosis in gastric cancer cells, suggesting its potential as a broad‐spectrum adjuvant to enhance chemotherapy efficacy via apoptotic signalling [ 37 ]. In GBM, cellular metabolism is profoundly altered, with intense metabolic activity and basal oxidative stress levels.…”