1993
DOI: 10.1016/1010-7940(93)90256-b
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Abstract: Following cardiac surgery, electrocardiography and creatine kinase isoenzyme MB (CK-MB) activities are of limited value in diagnosing a non-transmural infarction. With the recent availability of an assay to detect serial levels of the specific cardiocyte contractile protein troponin T the possibility has been increased of closing a diagnostic gap among cardiosurgical patients. Ninety patients with severe diffuse three-vessel disease undergoing myocardial revascularization were grouped by their postoperative el… Show more

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Cited by 37 publications
(11 citation statements)
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“…More sensitive and specific markers of myocardial injury and death are now available, and there is considerable interest in the use of serum troponin T (or troponin I) assays. 79,80 However, although these surrogate markers of myocardial injury have been used as a means of providing evidence for the concept of preconditioning in the human myocardium or to demonstrate the safety and tolerability of various pharmacological preconditioning agents in low-risk patients, they are by no means a substitute for hard end points of clinical outcome. It is only with direct evidence for an improved clinical outcome after ischemic and/or pharmacological preconditioning, which is more likely to be achieved in studies conducted in high-risk groups of patients, that preconditioning treatments may become a clinical reality.…”
Section: Yellon and Dana Clinical Ischemic Preconditioning 547mentioning
confidence: 99%
See 1 more Smart Citation
“…More sensitive and specific markers of myocardial injury and death are now available, and there is considerable interest in the use of serum troponin T (or troponin I) assays. 79,80 However, although these surrogate markers of myocardial injury have been used as a means of providing evidence for the concept of preconditioning in the human myocardium or to demonstrate the safety and tolerability of various pharmacological preconditioning agents in low-risk patients, they are by no means a substitute for hard end points of clinical outcome. It is only with direct evidence for an improved clinical outcome after ischemic and/or pharmacological preconditioning, which is more likely to be achieved in studies conducted in high-risk groups of patients, that preconditioning treatments may become a clinical reality.…”
Section: Yellon and Dana Clinical Ischemic Preconditioning 547mentioning
confidence: 99%
“…Even in patients with stable coronary artery disease, despite carefully controlled intraoperative ischemic periods and hypothermia, sensitive markers of tissue injury such as troponin T indicate that discrete necrosis occurs. 79,80 Moreover, as surgeons undertake more complex and higherrisk operations, the need for better preservation methods increases. In a situation such as CABG, the administration of an agent before surgery that could enhance myocardial defenses would reduce susceptibility to focal necrosis during surgery and permit the extension of the intraoperative ischemic period.…”
Section: Which Patients May Benefit?mentioning
confidence: 99%
“…Among those, the myocardium-specific troponin T is released in reversible and irreversible cell damage [4, 5, 6, 7, 8, 9, 10, 11]. Another sensitive, although unspecific set of markers for myocardial damage is free amino acids [12, 13].…”
Section: Introductionmentioning
confidence: 99%
“…This suggests that ischemic damage is occurring during these intervals and is consistent with previous reports. 8,10 -'' However, the variability in concentrations of cTnT and CK-MB mass for a given time frame indicates that other variables not included in this study are critical determinants of myocyte damage during surgery.…”
Section: Cardiac Markersmentioning
confidence: 99%