Tropicamide, a New Cycloplegic Mydriatic

Intraocular Pressure Increase Induced by 0.5% Tropicamide‐0.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy

“…This suggests that the reduction in ICA may have counteracted the effects of the expanded CC, leading to resistance in the aqueous humor outflow and stabilizing the IOP. These findings suggest that the ICA plays a critical role in IOP elevation, aligning with human medical studies that indicate the narrowing of the ICA following dilation can cause crowding in the angle, subsequently disrupting the trabecular meshwork's outflow facility and leading to an increase in IOP [6]. However, previous veterinary studies suggest that the geometric angle might be less significant in dogs compared to humans regarding glaucoma risk, as the trabecular meshwork in dogs is exposed differently, making it a less likely risk factor for glaucoma [11,17].…”

Intraocular Pressure Increase Induced by 0.5% Tropicamide‐0.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy

“…This suggests that the reduction in ICA may have counteracted the effects of the expanded CC, leading to resistance in the aqueous humor outflow and stabilizing the IOP. These findings suggest that the ICA plays a critical role in IOP elevation, aligning with human medical studies that indicate the narrowing of the ICA following dilation can cause crowding in the angle, subsequently disrupting the trabecular meshwork's outflow facility and leading to an increase in IOP [6]. However, previous veterinary studies suggest that the geometric angle might be less significant in dogs compared to humans regarding glaucoma risk, as the trabecular meshwork in dogs is exposed differently, making it a less likely risk factor for glaucoma [11,17].…”

Design and Development of a Novel Supportive Care Product for the Treatment of Sialorrhea in Parkinson’s Disease

“…Gross and microscopic examination of the kidney, liver, spleen and the eye revealed no pathology even in concentrations five times that which is used clinically. As reported by Gettes [88], prolonged topical application of tropicamide eye drops in animals found no evidence of any injury, acquired sensitivity, or allergic reaction to the eye. In an ocular irritation test, rabbits received 5 ocular instillations of 1% tropicamide solution five times daily for 5 days.…”

Comparative Analysis of Iridocorneal Angle in Cats and Dogs Using Ultrasound Biomicroscopy: Implications for Glaucoma Prevalence

“…Furthermore, dogs were found to have smaller ICA and AOD compared to cats. It is well-established that smaller ICA and AOD can contribute to the development of glaucoma in human medicine (22)(23)(24). A reduced ICA and AOD indicate an anterior and external displacement of the iris root, potentially leading to compromised access of aqueous humor to the trabecular meshwork (25,26).…”

Intraocular Pressure Increase Induced by 0.5% Tropicamide‐0.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy

“…This suggests that the reduction in ICA may have counteracted the effects of the expanded CC, leading to resistance in the aqueous humor outflow and stabilizing the IOP. These findings suggest that the ICA plays a critical role in IOP elevation, aligning with human medical studies that indicate the narrowing of the ICA following dilation can cause crowding in the angle, subsequently disrupting the trabecular meshwork's outflow facility and leading to an increase in IOP [6]. However, previous veterinary studies suggest that the geometric angle might be less significant in dogs compared to humans regarding glaucoma risk, as the trabecular meshwork in dogs is exposed differently, making it a less likely risk factor for glaucoma [11,17].…”

Design and Development of a Novel Supportive Care Product for the Treatment of Sialorrhea in Parkinson’s Disease

“…Gross and microscopic examination of the kidney, liver, spleen and the eye revealed no pathology even in concentrations five times that which is used clinically. As reported by Gettes [88], prolonged topical application of tropicamide eye drops in animals found no evidence of any injury, acquired sensitivity, or allergic reaction to the eye. In an ocular irritation test, rabbits received 5 ocular instillations of 1% tropicamide solution five times daily for 5 days.…”

Comparative Analysis of Iridocorneal Angle in Cats and Dogs Using Ultrasound Biomicroscopy: Implications for Glaucoma Prevalence

“…Furthermore, dogs were found to have smaller ICA and AOD compared to cats. It is well-established that smaller ICA and AOD can contribute to the development of glaucoma in human medicine (22)(23)(24). A reduced ICA and AOD indicate an anterior and external displacement of the iris root, potentially leading to compromised access of aqueous humor to the trabecular meshwork (25,26).…”

Intraocular Pressure Increase Induced by 0.5% Tropicamide‐0.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy

“…This suggests that the reduction in ICA may have counteracted the effects of the expanded CC, leading to resistance in the aqueous humor outflow and stabilizing the IOP. These findings suggest that the ICA plays a critical role in IOP elevation, aligning with human medical studies that indicate the narrowing of the ICA following dilation can cause crowding in the angle, subsequently disrupting the trabecular meshwork's outflow facility and leading to an increase in IOP [6]. However, previous veterinary studies suggest that the geometric angle might be less significant in dogs compared to humans regarding glaucoma risk, as the trabecular meshwork in dogs is exposed differently, making it a less likely risk factor for glaucoma [11,17].…”

Design and Development of a Novel Supportive Care Product for the Treatment of Sialorrhea in Parkinson’s Disease

“…Gross and microscopic examination of the kidney, liver, spleen and the eye revealed no pathology even in concentrations five times that which is used clinically. As reported by Gettes [88], prolonged topical application of tropicamide eye drops in animals found no evidence of any injury, acquired sensitivity, or allergic reaction to the eye. In an ocular irritation test, rabbits received 5 ocular instillations of 1% tropicamide solution five times daily for 5 days.…”

Comparative Analysis of Iridocorneal Angle in Cats and Dogs Using Ultrasound Biomicroscopy: Implications for Glaucoma Prevalence

“…Furthermore, dogs were found to have smaller ICA and AOD compared to cats. It is well-established that smaller ICA and AOD can contribute to the development of glaucoma in human medicine (22)(23)(24). A reduced ICA and AOD indicate an anterior and external displacement of the iris root, potentially leading to compromised access of aqueous humor to the trabecular meshwork (25,26).…”